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Active Recombinant Human TP53, His-tagged

Cat.No. : TP53-611H
Product Overview : Recombinant Human TP53 (Accession # NP_000537) , fused with an N-terminal Ser-Tyr-Tyr and 6-His tag, was produced in E. coli-derived.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His
Form : Supplied as a solution in HEPES, NaCl, and Glycerol.
Bio-activity : Recombinant Human His6-p53 is ideal for use as a control substrate for in vitro Ubiquitin conjugation. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human His6-p53 concentration of 0.5-2.5 µM.
Molecular Mass : Recombinant Human TP53, His-tagged has a calculated MW of 45 kDa.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme [ Homo sapiens ]
Official Symbol : PPP3CA
Synonyms : PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme; CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; calcineurin A alpha; CNA1; PPP2B; protein phosphatase 2B; catalytic subunit; alpha isoform; CAM-PRP catalytic subunit; calmodulin-dependent calcineurin A subunit alpha isoform; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; CALN; CCN1; CALNA; CALNA1;
Gene ID : 5530
mRNA Refseq : NM_000944
Protein Refseq : NP_000935
MIM : 114105
UniProt ID : Q08209
Chromosome Location : 4q24

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TP53 status be used for cancer risk assessment and screening in individuals with a family history of cancer? 07/21/2022

Yes, identifying TP53 mutations in families with a history of early-onset cancers can help identify individuals at high risk for cancer and guide screening and prevention strategies.

What are the challenges in developing targeted therapies for TP53-mutated cancers? 05/21/2019

TP53 mutations are highly diverse, making it challenging to develop a one-size-fits-all therapy. Additionally, the p53 pathway is complex, and disrupting it can have unintended consequences.

Can TP53 status influence eligibility for certain clinical trials? 12/06/2018

Yes, TP53 mutation status can be a criterion for eligibility in specific clinical trials, especially those testing experimental treatments that may target the p53 pathway.

How might TP53 status affect decisions regarding surgery, chemotherapy, and radiation therapy? 08/13/2017

TP53 status can influence treatment decisions. For example, patients with TP53 mutations may require more aggressive treatment approaches or different chemotherapy regimens.

Are there targeted therapies specifically designed for TP53-mutated cancers? 06/05/2016

Currently, there are no specific targeted therapies approved solely for TP53-mutated cancers. However, research is ongoing to develop drugs that target the altered p53 pathway.

Customer Reviews (3)

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Reviews
02/26/2023

    By actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the TP53 protein.

    11/05/2020

      This flexibility allows for tailored approaches and provides researchers with more options to study specific aspects of TP53 biology or its interactions with other molecules.

      07/24/2017

        Manufacturers can provide comprehensive product information, including data on the functionality, stability, and handling of TP53 protein.

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