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Recombinant Human CDK4, His-tagged

Cat.No. : CDK4-16H
Product Overview : Recombinant Human Cyclin-Dependent Kinase 4 is expressed inE. colias a full-length protein having a molecular weight of 38 kDa fused to an amino terminal hexahistidine tag. The CDK4 is purified by proprietary chromatographic techniques.
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Cat. No. : CDK4-16H
Description : Cyclin-dependent kinase 4 combines with the protein cyclin D to form a protein complex that promotes the passage of cells through the G1 checkpoint in the cell growth cycle. This cellular activity is regulated by the protein p16 produced by p16INK4a. Normally, p16 controls cell growth by inhibiting the activity of the CDK4–cyclin D complex and stopping cells at the G1 checkpoint.
Source : Escherichia Coli.
Purity : Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.
Formulation : CDK4 is supplied in 1x Laemmli Buffer (25mM Tris-HCl Ph-6.8, 50mM DTT, 1% (w/v) SDS, 0.1%(w/v) Bromophenol Blue and 2.5% Glycerol).
Application : CDK-4 can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
Storage : Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : CDK4 cyclin-dependent kinase 4 [ Homo sapiens ]
Synonyms : cyclin-dependent kinase 4; CMM3; PSK-J3; MGC14458; CDK4; cell division kinase 4; melanoma cutaneous malignant, 3; EC 2.7.11.22
Gene ID : 1019
mRNA Refseq : NM_000075
Protein Refseq : NP_000066
MIM : 123829
UniProt ID : P11802
Chromosome Location : 12q14
Pathway : Bladder cancer; Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Small cell lung cancer; T cell receptor signaling pathway; Tight junction; p53 signaling pathway; Cell Cycle, Mitotic
Function : cyclin-dependent protein kinase activity; ATP binding; nucleotide binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential challenges in targeting CDK4 for cancer therapy? 11/24/2022

Resistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.

Can CDK4 be targeted for cancer therapy? 06/16/2022

Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.

How is CDK4 clinically relevant? 06/30/2020

CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.

Which cancers are commonly associated with CDK4 overactivity? 06/19/2020

CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.

How does CDK4 relate to cell senescence? 05/31/2016

CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.

Customer Reviews (3)

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Reviews
02/18/2023

    Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

    02/16/2020

      They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.

      05/29/2018

        The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

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