Active Recombinant Human ITGAV&ITGB6

• Cat.No.: ITGAV&ITGB6-741H
• Product Overview: Recombinant Human ITGAV&ITGB6 (Accession # NP_002201 (Integrin alpha V) & P18564 (Integrin beta 6)) was produced in Chinese Hamster Ovary cell line, CHO-derived.

Specification

• Source: CHO cells
• Species: Human
• Predicted N Terminal: Phe31 ( alpha V subunit) & Gly22 ( beta 6 subunit)
• Form: Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and CaCl2.
• Bio-activity: Measured by its binding ability in a functional ELISA.Immobilized Recombinant Human Integrin alpha V beta 6 at 2.0 µg/mL can bind Recombinant Human LAP TGF-beta 1 with an apparent KD <0.1 nM.
• Molecular Mass: Recombinant Human ITGAV&ITGB6 has a calculated MW of 110.5 kDa ( alpha V subunit), 78.6 kDa ( beta 6 subunit). In SDS-PAGE migrates as 145 kDa and 115 kDa, reducing conditions.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: ITGAV integrin, alpha V [ Homo sapiens ]
• Official Symbol: ITGAV
• Synonyms: ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; VNRA; VTNR; DKFZp686A08142
• Gene ID: 3685
• mRNA Refseq: NM_001144999
• Protein Refseq: NP_001138471
• MIM: 193210
• UniProt ID: P06756
• Chromosome Location: 2q31-q32