"RIPK2" Related Products

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Recombinant Human RIPK2, His-tagged, Active

Cat.No. : RIPK2-419H
Product Overview : Recombinant Human RIPK2, Catalytic Domain (amino acids 1-299), fused with His-tagged, expressed in insect cells.
Description : This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.
Source : Insect cells
Species : Human
Tag : His
Form : 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton® X–100, 2 mM DTT and 50% Glycerol.
Bio-activity : 37 nmoles of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30 centigrade. Activity determined at a final protein concentration of 16.7 μg/mL.
Molecular Mass : 38.9 kDa. Calculated from the protein sequence(s)
Protein length : amino acids 1-299
Purity : 75% as determined by a Coomassie® blue stained SDS-PAGE gel.
Storage : For maximum recovery please spin prior to use. Aliquots of the 5 ug, 10ug and 20ug sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at ?80 centigrade, this product is guaranteed for 6 months from date of purchase.
Concentration : 0.47 mg/mL total protein as measured using the Bradford protein assay with BSA as a standard.
Dilutions : 20 mM Tris (pH 7.5), 0.02% Triton® X?100, 0.1 mg/mL BSA, 2 mM DTT, 0.5 mM Na3VO4 and 10% Glycerol.
Shipping : dry ice
Gene Name : RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
Official Symbol : RIPK2
Synonyms : CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; receptor-interacting serine/threonine-protein kinase 2; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; RIP-2; growth-inhibiting gene 30; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; tyrosine-protein kinase RIPK2
Gene ID : 8767
mRNA Refseq : NM_003821
Protein Refseq : NP_003812
MIM : 603455
UniProt ID : O43353
Chromosome Location : 8q21
Pathway : Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem
Function : ATP binding; CARD domain binding; LIM domain binding

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