Active Recombinant Human RIPK2, His-tagged
Cat.No. : | RIPK2-419H |
Product Overview : | Recombinant Human RIPK2, Catalytic Domain (amino acids 1-299), fused with His-tagged, expressed in insect cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton® X–100, 2 mM DTT and 50% Glycerol. |
Bio-activity : | 37 nmoles of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30 centigrade. Activity determined at a final protein concentration of 16.7 μg/mL. |
Molecular Mass : | 38.9 kDa. Calculated from the protein sequence(s) |
Protein length : | amino acids 1-299 |
Purity : | 75% as determined by a Coomassie® blue stained SDS-PAGE gel. |
Storage : | For maximum recovery please spin prior to use. Aliquots of the 5 ug, 10ug and 20ug sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at ?80 centigrade, this product is guaranteed for 6 months from date of purchase. |
Concentration : | 0.47 mg/mL total protein as measured using the Bradford protein assay with BSA as a standard. |
Dilutions : | 20 mM Tris (pH 7.5), 0.02% Triton® X?100, 0.1 mg/mL BSA, 2 mM DTT, 0.5 mM Na3VO4 and 10% Glycerol. |
Shipping : | dry ice |
Gene Name : | RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ] |
Official Symbol : | RIPK2 |
Synonyms : | CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; receptor-interacting serine/threonine-protein kinase 2; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; RIP-2; growth-inhibiting gene 30; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; tyrosine-protein kinase RIPK2 |
Gene ID : | 8767 |
mRNA Refseq : | NM_003821 |
Protein Refseq : | NP_003812 |
MIM : | 603455 |
UniProt ID : | O43353 |
Chromosome Location : | 8q21 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem |
Function : | ATP binding; CARD domain binding; LIM domain binding |
Products Types
◆ Recombinant Protein | ||
RIPK2-5564H | Recombinant Human RIPK2 Protein, His-tagged | +Inquiry |
RIPK2-7616M | Recombinant Mouse RIPK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
RIPK2-5565H | Recombinant Human RIPK2, GST-tagged | +Inquiry |
Ripk2-5522M | Recombinant Mouse Ripk2 Protein, Myc/DDK-tagged | +Inquiry |
RIPK2-29983TH | Recombinant Human RIPK2 | +Inquiry |
◆ Lysates | ||
RIPK2-2333HCL | Recombinant Human RIPK2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1623 | RIPK2 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionRIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.
RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.
Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.
RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.
RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.
RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.
Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.
Customer Reviews (3)
Write a reviewPrecise mass spectrometry analysis, key for our proteomics investigations.
Dependable protein purification, consistently delivers high yield and purity.
Great antibody validation, enhances our immunoprecipitation success.
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