Recombinant Human FLT3LG


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Recombinant Human FLT3LG

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Cat.No. : FLT3LG-1235H
Product Overview : Recombinant Human Flt3-Ligand is a soluble 17.6kDa polypeptide containing 155 amino acid residues, which comprises of the extracellular transmembrane domain of the Flt3-ligand protein. Flt3-ligand (flk2-ligand) stimulates the proliferation and colony formation of certain BM precursor cells including CD34+ cells.
Description : Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3-LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8(see MIM 186910)-positive classical DCs and their CD103-positive tissue counterparts.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2μm filtered solution in 20mM Tris-HCl, 20mM NaCl, pH7.4.
Bio-activity : rHuFlt3-L is fully biologically active when compared to standards. Its specific activity is .1.106 units/mg.
Endotoxin : ≤1EU/μg, determined by the LAL method.
Purity : ≥98%, as determined by SDS-PAGE and HPLC method.
Storage : Lyophilized samples are stable for greater than six months from date of receipt at -20 centigrade to -70 centigrade. The reconstituted samples should be stored under sterile condition in working aliquots at -20 centigrade to -70 centigrade. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized rHuFlt3-L in sterile ddH2O not less than 100μg/ml of the cytokine solution.
Gene Name : FLT3LG fms-related tyrosine kinase 3 ligand [ Homo sapiens ]
Official Symbol : FLT3LG
Synonyms : FL; FLT3L; fms-related tyrosine kinase 3 ligand; flt3 ligand
Gene ID : 2323
mRNA Refseq : NM_001204502
Protein Refseq : NP_001191431
MIM : 600007
UniProt ID : P49771
Chromosome Location : 19q13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Pathways in cancer, organism-specific biosystem
Function : cytokine activity; protein homodimerization activity; receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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