Recombinant Human CA2 CA2-219H

Recombinant Human CA2


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Recombinant Human CA2

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Cat.No. : CA2-219H
Product Overview : Recombinant Human CA2 was expressed in E. coli.
Description : Carbonic anhydrase is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital physiological and pathological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. It is required for renal acidification. Its absence can lead to osteoporosis, renal tubular acidosis, and cerebral calcification. Therefore, this enzyme is an important target for inhibitors with clinical applications in glaucoma, epilepsy and Parkinson’s disease. In addition, it is being explored as a potential target for obesity and cancer. CAII has a molecular mass of approximately 30 kDa and is primarily present in type II pneumocytes. Due to this unique location it has been speculated that CAII is involved in pulmonary functions such as regulation of fluid secretion and facilitation of CO2 elimation. Sulfonamides, sulfamates and sulfamides are potent inhibitors of CA.
Source : E. coli
Species : Human
Form : Supplied as a solution in 20 mM Tris, pH 7.5, with 150 mM NaCl.
Bio-activity : ≥5,000 units/mg protein
Unit Definition : One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)
Applications : Human carbonic anhydrase II has been used in a study to assess quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. Human carbonic anhydrase II has also been used in a study to investigate a new scrubber concept for catalytic CO2 hydration.
Storage : Store at −20°C
Concentration : 800 - 1000 μg/Ml
Gene Name : CA2 carbonic anhydrase II [ Homo sapiens ]
Official Symbol : CA2
Synonyms : CAC; CAII; Car2; CA-II; HEL-76; carbonic anhydrase 2; carbonate dehydratase II; carbonic anhydrase B; carbonic anhydrase C; carbonic dehydratase; epididymis luminal protein 76
Gene ID : 760
mRNA Refseq : NM_000067
Protein Refseq : NP_000058
MIM : 611492
UniProt ID : P00918
Chromosome Location : 8q22
Pathway : Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Collecting duct acid secretion, conserved biosystem
Function : arylesterase activity; carbonate dehydratase activity; protein binding

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