"VEGFB" Related Products


Recombinant Human VEGFB, His-tagged

Cat.No.: VEGFB-17H
Product Overview: Recombinant Human VEGFB(Pro 22 - Ala 207) fussed with His tag at C-terminal was expressed in HEK293.
Description: Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Source: HEK293
Species: Human
Tag: His
Predicted N Terminal: Pro 22
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: The EC50 is typically 0.01-0.12 μg/mL.
Molecular Mass: Has a calculated MW of 20.2 kDa, DTT-reduced Protein migrates as 15-18 kDa and 33-35 kDa in SDS-PAGE.
Endotoxin: Less than 1.0 EU per μg of the rh VEGFB 186 by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name: VEGFB vascular endothelial growth factor B [ Homo sapiens ]
Official Symbol: VEGFB
Synonyms: VRF; VEGFL; vascular endothelial growth factor B; VEGF-related factor
Gene ID: 7423
mRNA Refseq: NM_003377
Protein Refseq: NP_003368
MIM: 601398
UniProt ID: P49765
Chromosome Location: 11q13
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Focal adhesion, organism-specific biosystem
Function: chemoattractant activity; growth factor activity; heparin binding

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