"PGF" Related Products


Recombinant Human PGF, His-tagged

Cat.No.: PGF-29H
Product Overview: Recombinant Human PGF(Leu 19 - Arg 170 ) fussed with 6×His tag at C-terminal was expressed in HEK293.
Description: Placental growth factor (PGF) also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Source: HEK293
Species: Human
Tag: His
Predicted N Terminal: Leu 19
Form: Lyophilized from 0.22 μm filtered solution in 100 mM acetic acid, pH2-3. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Bio-activity: The ED50 for this effect is typically 1 - 10 μg/ml.
Molecular Mass: Has a calculated MW of 20.2 kDa, DTT-reduced Protein migrates as 28-33 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rhPGF by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade-8 centigrade); After reconstitution under sterile conditions for 1 month (4 centigrade-8 centigrade) or 3 months (-20 centigrade to -70 centigrade).
Gene Name: PGF placental growth factor [ Homo sapiens ]
Official Symbol: PGF
Synonyms: PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760; placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein
Gene ID: 5228
mRNA Refseq: NM_002632
Protein Refseq: NP_002623
MIM: 601121
UniProt ID: P49763
Chromosome Location: 14q24.3
Pathway: Focal Adhesion, organism-specific biosystem; PI3K-Akt signaling pathway, organism-specific biosystem; Rap1 signaling pathway, organism-specific biosystem
Function: growth factor activity; heparin binding; protein binding

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