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Recombinant Human KLK6

Cat.No. : KLK6-3929H
Product Overview : Recombinant Human KLK6(Met1-Lys244) was expressed with six amino acids (LEVLFQ) at the C- terminus.
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Description : KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Source : Human Cells
Species : Human
Predicted N Terminal : Glu 17
Form : Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements.
Molecular Mass : The recombinant human KLK6 consists 235 amino acids and predicts a molecular mass of 25.9 kDa.
Protein length : Met1-Lys244
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : > (61.6 +34.0) % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -231 centigrade
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : KLK6 kallikrein-related peptidase 6 [ Homo sapiens ]
Official Symbol : KLK6
Synonyms : KLK6; kallikrein-related peptidase 6; kallikrein 6 (neurosin, zyme) , protease, serine, 18 , PRSS9, PRSS18; kallikrein-6; Bssp; Klk7; neurosin; zyme; protease M; serine protease 9; serine protease 18; hK6; SP59; PRSS9; PRSS18; MGC9355;
Gene ID : 5653
mRNA Refseq : NM_002774
Protein Refseq : NP_002765
MIM : 602652
UniProt ID : Q92876
Chromosome Location : 19q13.3
Pathway : Alpha-synuclein signaling, organism-specific biosystem;
Function : peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the association between Klk6 recombinant protein and tumors? 09/07/2022

Studies have shown that Klk6 recombinant protein may be involved in the occurrence and progression of tumors, especially in pancreatic and gastric cancers.

What is the status of Klk6 recombinant protein in pregnant women? 07/07/2022

The level of Klk6 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

What are the treatments for Klk6 recombinant protein? 01/08/2022

The current treatments for Klk6 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for trypsin activity.

Is Klk6 recombinant protein associated with other systemic diseases? 06/19/2021

Studies have shown that Klk6 recombinant protein may be associated with cardiovascular diseases, liver diseases, and lung diseases.

Does the Klk6 recombinant protein have a role in humans? 09/26/2020

Klk6 recombinant protein is mainly involved in the digestive process in the human body, helping to break down proteins in food.

If the level of Klk6 recombinant protein is abnormal, what should I do? 05/15/2020

If the level of Klk6 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Customer Reviews (3)

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Reviews
06/15/2023

    When experimenting with the KLK6, clear and consistent results are available for easy data analysis and interpretation.

    02/15/2023

      KLKKLK6 products are available in a wide range of specifications for experimental designs of different sizes and needs.

      04/19/2021

        KLK6 has a long half-life and is able to maintain stability and reliability during experiments.

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