Recombinant Human ABCG2, GST-tagged

• Cat.No.: ABCG2-19H
• Product Overview: Recombinant Human ABCG2(1 a.a. - 655 a.a.) fussed with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 98.7 kDa
• AA Sequence: MSSSNVEVFIPVSQGNTNGFPATAS NDLKAFTEGAVLSFHNICYRVKLKS GFLPCRKPVEKEILSNINGIMKPGL NAILGPTGGGKSSLLDVLAARKDPS GLSGDVLINGAPRPANFKCNSGYVV QDDVVMGTLTVRENLQFSAALRLAT TMTNHEKNERINRVIQELGLDKVAD SKVGTQFIRGVSGGERKRTSIGMEL ITDPSILFLDEPTTGLDSSTANAVL LLLKRMSKQGRTIIFSIHQPRYSIF KLFDSLTLLASGRLMFHGPAQEALG YFESAGYHCEAYNNPADFFLDIING DSTAVALNREEDFKATEIIEPSKQD KPLIEKLAEIYVNSSFYKETKAELH QLSGGEKKKKITVFKEISYTTSFCH QLRWVSKRSFKNLLGNPQASIAQII VTVVLGLVIGAIYFGLKNDSTGIQN RAGVLFFLTTNQCFSSVSAVELFVV EKKLFIHEYISGYYRVSSYFLGKLL SDLLPMRMLPSIIFTCIVYFMLGLK PKADAFFVMMFTLMMVAYSASSMAL AIAAGQSVVSVATLLMTICFVFMMI FSGLLVNLTTIASWLSWLQYFSIPR YGFTALQHNEFLGQNFCPGLNATGN NPCNYATCTGEEYLVKQGIDLSPWG LWKNHVALACMIVIFLTIAYLKLLF LKKYS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) [ Homo sapiens ]
• Official Symbol: ABCG2
• Synonyms: MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1; EST157481; ATP-binding cassette sub-family G member 2; ABC transporter; ATP-binding cassette transporter G2; breast cancer resistance protein; mitoxantrone resistance-associated protein; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; urate exporter
• Gene ID: 9429
• mRNA Refseq: NM_001257386
• Protein Refseq: NP_001244315
• MIM: 603756
• UniProt ID: Q9UNQ0
• Chromosome Location: 4q22
• Pathway: ABC transporters, organism-specific biosystem; Abacavir transmembrane transport, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem
• Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; heme transporter activity