Active Recombinant Human TLR4 Protein, Ser & His-tagged
Cat.No. : | TLR4-886H |
Product Overview : | Recombinant Human TLR4 (Accession # O00206) Glu24-Lys631, fused with a C-terminal Ser and 10-His tag, was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian cells |
Species : | Human |
Tag : | Ser & His |
Predicted N Terminal : | Glu24 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA.When Recombinant Human (rh) TLR4 is Immobilized at 2 µg/mL (100 µL/well), the concentration of rhMD2 that produces 50% optimal binding response is found to be approximately 0.03 - 0.15 µg/mL. |
Molecular Mass : | Recombinant Human TLR4, Ser & His-tagged has a calculated MW of 70.6 kDa. In SDS-PAGE migrates as 90-95 kDa, reducing conditions. |
Protein length : | Glu24-Lys631 |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | TLR4 toll-like receptor 4 [ Homo sapiens ] |
Official Symbol : | TLR4 |
Synonyms : | TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10; |
Gene ID : | 7099 |
mRNA Refseq : | NM_003266 |
Protein Refseq : | NP_003257 |
MIM : | |
UniProt ID : | O00206 |
Chromosome Location : | 9q33.1 |
Products Types
◆ Recombinant Protein | ||
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TLR4-5741R | Recombinant Rat TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TLR4-290H | Active Recombinant Human TLR4 Protein, His-tagged | +Inquiry |
TLR4-421G | Recombinant Goat TLR4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TLR4-402HCL | Recombinant Human TLR4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.
Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.
The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.
TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.
TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.
Customer Reviews (3)
Write a reviewPrecision in every experiment—this product is a game-changer for us.
Timely delivery is key, and this product arrived on schedule.
Exceptional customer service—knowledgeable staff guided us through the selection process.
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