Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human TLR4 Protein, Ser & His-tagged

Cat.No. : TLR4-886H
Product Overview : Recombinant Human TLR4 (Accession # O00206) Glu24-Lys631, fused with a C-terminal Ser and 10-His tag, was produced in Mouse myeloma cell line, NS0-derived.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian cells
Species : Human
Tag : Ser & His
Predicted N Terminal : Glu24
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.When Recombinant Human (rh) TLR4 is Immobilized at 2 µg/mL (100 µL/well), the concentration of rhMD2 that produces 50% optimal binding response is found to be approximately 0.03 - 0.15 µg/mL.
Molecular Mass : Recombinant Human TLR4, Ser & His-tagged has a calculated MW of 70.6 kDa. In SDS-PAGE migrates as 90-95 kDa, reducing conditions.
Protein length : Glu24-Lys631
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : TLR4 toll-like receptor 4 [ Homo sapiens ]
Official Symbol : TLR4
Synonyms : TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10;
Gene ID : 7099
mRNA Refseq : NM_003266
Protein Refseq : NP_003257
MIM :
UniProt ID : O00206
Chromosome Location : 9q33.1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does TLR4 signaling intersect with the nuclear factor-kappa B (NF-κB) pathway? 11/20/2021

TLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.

Can you explain the molecular events following TLR4 activation upon ligand binding? 08/14/2020

Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.

What is the role of the TLR4 signaling pathway in innate immunity? 02/18/2019

The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.

Can you elaborate on the crosstalk between TLR4 and other pattern recognition receptors (PRRs)? 10/02/2018

TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.

Can you describe the molecular structure of TLR4 and its functional domains? 04/23/2018

TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.

Customer Reviews (3)

Write a review
Reviews
12/29/2020

    Precision in every experiment—this product is a game-changer for us.

    04/07/2019

      Timely delivery is key, and this product arrived on schedule.

      08/06/2018

        Exceptional customer service—knowledgeable staff guided us through the selection process.

        Ask a Question for All TLR4 Products

        Required fields are marked with *

        My Review for All TLR4 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends