Recombinant Human LGR5 Protein, Fc Chimera


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Recombinant Human LGR5 Protein, Fc Chimera

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Cat.No. : LGR5-1037H
Product Overview : Recombinant Human LGR5 (Accession # O75473), fused with , was produced in Chinese Hamster Ovary cell line, CHO-derived.
Source : CHO Cells
Species : Human
Tag : Fc
Predicted N Terminal : Gly22
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.When Recombinant Human R-Spondin 3 is coated at 0.5 µg/mL, Recombinant Human Lgr5/GPR49 Fc Chimera binds with an apparent Kd <0.1 nM. Measured by its ability to inhibit Topflash reporter activity in HEK293T human embryonic kidney cells.The ED50 for this effect is typically 1.5-7.5 µg/mL in the presence of 20 ng/mL Recombinant Human R-Spondin 2 and 5 ng/mL Recombinant Mouse Wnt-3a.
Molecular Mass : Recombinant Human LGR5, Fc Chimera has a calculated MW of 87 kDa (monomer). In SDS-PAGE migrates as 90-110 kDa, reducing conditions.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : LGR5 leucine-rich repeat containing G protein-coupled receptor 5 [ Homo sapiens ]
Official Symbol : LGR5
Synonyms : LGR5; leucine-rich repeat containing G protein-coupled receptor 5; G protein coupled receptor 49 , GPR49, GPR67, leucine rich repeat containing G protein coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; FEX; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; orphan G protein-coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5; GPR49; GPR67; GRP49; MGC117008;
Gene ID : 8549
mRNA Refseq : NM_003667
Protein Refseq : NP_003658
MIM : 606667
UniProt ID : O75473
Chromosome Location : 12q22-q23
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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