Recombinant Human BRD7, GST-tagged BRD7-12H

Recombinant Human BRD7, GST-tagged


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Recombinant Human BRD7, GST-tagged

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Cat.No. : BRD7-12H
Product Overview : Recombinant Human BRD7 (a.a.129-252) fussed with GST tag at N-terminal was expressed in E. coli.
Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD7 is a subunit of the polybromo-associated BRG1-associated factor (PBAF)-specific component of the switch/sucrose non-fermentable chromatin-remodeling complex. It has a tumor suppressor role by acting as a cofactor for p53 and regulating breast cancer tumorigenicity. Cells lacking BRD7 have reduced breast cancer type 1-dependent estrogen receptor α expression. Down-regulation of BRD7 has been demonstrated in nasopharyngeal carcinoma cell lines and in colorectal cancer. BRD7 is also involved in transcriptional gene silencing through binding to protein arginine methyltransferase 5 and polycomb repressive complex 2. This protein product contains the bromodomain region of BRD7.
Source : E. coli
Species : Human
Tag : GST
Form : 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Molecular Mass : 42.2 kDa
Purity : ≥40%
Storage : Store at -80 centigrade
Gene Name : BRD7 bromodomain containing 7 [ Homo sapiens ]
Official Symbol : BRD7
Synonyms : BP75; NAG4; CELTIX1; bromodomain-containing protein 7; 75 kDa bromodomain protein; protein CELTIX-1
Gene ID : 29117
mRNA Refseq : NM_001173984
Protein Refseq : NP_001167455
UniProt ID : Q9NPI1
Chromosome Location : 16q12
Pathway : Wnt Signaling Pathway NetPath, organism-specific biosystem
Function : histone binding; lysine-acetylated histone binding; p53 binding

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