Active Recombinant Human TNFRSF10A, Fc-tagged, Biotinylated

• Cat.No.: TNFRSF10A-597H
• Product Overview: The recombinant human DR4-Fc fusion is expressed as a 445 amino acid protein consisting of Ala24 - Asn239 region of DR4 (UniProt accession #O00220) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
• Bio-activity: Binds to its ligand human TRAIL and inhibits TRAIL-mediated signaling activity including TRAIL--induced cytotoxicity in L-929 mouse fibroblast cells.
• Molecular Mass: Calculated molecular mass (kDa): 48.5; Estimated by SDS-PAGE under reducing condition (kDa): 50-55
• Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
• Official Symbol: TNFRSF10A
• Synonyms: TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365
• Gene ID: 8797
• mRNA Refseq: NM_003844
• Protein Refseq: NP_003835
• MIM: 603611
• UniProt ID: O00220
• Chromosome Location: 8p21
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem
• Function: TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding