Recombinant Human TNFRSF10A, Fc-tagged, Biotinylated

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Recombinant Human TNFRSF10A, Fc-tagged, Biotinylated

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Cat.No. : TNFRSF10A-597H
Product Overview : The recombinant human DR4-Fc fusion is expressed as a 445 amino acid protein consisting of Ala24 - Asn239 region of DR4 (UniProt accession #O00220) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand human TRAIL and inhibits TRAIL-mediated signaling activity including TRAIL--induced cytotoxicity in L-929 mouse fibroblast cells.
Molecular Mass : Calculated molecular mass (kDa): 48.5; Estimated by SDS-PAGE under reducing condition (kDa): 50-55
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
Official Symbol : TNFRSF10A
Synonyms : TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; APO2; TRAILR1; TRAILR-1; MGC9365;
Gene ID : 8797
mRNA Refseq : NM_003844
Protein Refseq : NP_003835
MIM : 603611
UniProt ID : O00220
Chromosome Location : 8p21
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem;
Function : TRAIL binding; death receptor activity; protein binding; receptor activity; transcription factor binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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