Recombinant Mouse Il6 protein Il6-12M

Recombinant Mouse Il6 protein

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Recombinant Mouse Il6 protein

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Cat.No. : Il6-12M
Product Overview : Recombinant Mouse Il6 protein was expressed in Escherichia coli.
Description : Interleukin-6 (IL-6) encoded by the IL-6 gene, acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. The mouse IL-6 is a single non-glycosylated polypeptide chain containing 187 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain (CD126), and the signal- transducing component gp130 (also called CD130). The mouse IL-6 shares 40 % and 85 % a.a. sequence identity with human and rat IL-6 and it is equally active on human and rat cells.
Source : E.coli
Species : Mouse
Form : Lyophilized from a 0.2μm filtered solution in 30 mM Acetic Acid, pH 3.0, 150 mM NaCl, 5 % Trehalose, 0.02 % Tween-20.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is less than 0.02 ng/ml, corresponding to a specific activity of > 5 × 10⁷ IU/mg.
Molecular Mass : Approximately 21.7 kDa, a single non-glycosylated polypeptide chain containing 188 amino acids.
Protein length : 188
AA Sequence : MFPTSQVRRGDFTED TTPNRPVYTTSQVGG LITHVLWEIVEMRKE LCNGNSDCMNNDDAL AENNLKLPEIQRNDG CYQTGYNQEICLLKI SSGLLEYHSYLEYMK NNLKDNKKDKARVLQ RDTETLIHIFNQEVK DLHKIVLPTPISNAL LTDKLESQKEWLRTK TIQFILKSLEEFLKV TLRSTRQT
Endotoxin : Less than 1 EU/µg of rMuIL-6 as determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
SDS-PAGE of Il6-12M :

Gene Name : Il6
Official Symbol : Il6
Synonyms : IL6; interleukin 6; interleukin-6; interleukin HP-1; B-cell hybridoma growth factor; Il-6;
Gene ID : 16193
mRNA Refseq : NM_031168
Protein Refseq : NP_112445
UniProt ID : P08505

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