Recombinant Mouse Il6 protein

Cat.No.: Il6-12M
Product Overview: Recombinant Mouse Il6 is a single, non-glycosylated polypeptide chain.
Description: Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages. IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis.
Source: E. coli
Species: Mouse
Form: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.02 ng/ml, corresponding to a specific activity of > 50,000,000 units/mg.
Molecular Mass: 21709 Dalton
AA Sequence: FPTSQVRRGD FTEDTTPNRP VYTTSQVGGL ITHVLWEIVE MRKELCNGNS DCMNNDDALA ENNLKLPEIQ RNDGCYQTGY NQEICLLKIS SGLLEYHSYL EYMKNNLKDN KKDKARVLQR DTETLIHIFN QEVKDLHKIV LPTPISNALL TDKLESQKEW LRTKTIQFIL KSLEEFLKVT LRSTRQT
Purity: Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Usage: For LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Stability: Lyophilized Interleukin-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution IL6 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Reconstitution: It is recommended to reconstitute the lyophilized Mouse Il-6 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name: Il6 interleukin 6 [ Mus musculus ]
Official Symbol: Il6
Synonyms: Il-6; interleukin-6; B-cell hybridoma growth factor; interleukin HP-1
Gene ID: 16193
mRNA Refseq: NM_031168
Protein Refseq: NP_112445
UniProt ID: P08505
Chromosome Location: 5 B1; 5 15.7 cM
Pathway: ARMS-mediated activation, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Adipogenesis, organism-specific biosystem
Function: cytokine activity; growth factor activity; interleukin-6 receptor binding

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