Recombinant Human PRKCH protein, GST/His-tagged PRKCH-19H

Recombinant Human PRKCH protein, GST/His-tagged

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Recombinant Human PRKCH protein, GST/His-tagged

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Cat.No. : PRKCH-19H
Product Overview : Recombinant Human PRKCH (amino acids M1-P683 ) fussed with GST/HIS tag at N-terminal with a Thrombin cleavage site was expressed in Baculovirus infected Sf9 cells.
Description : Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
Source : Insect Cells
Species : Human
Tag : GST/His
Form : 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol
Bio-activity : 71 pmol/µg×min
Molecular Mass : 107,425 Da
Storage : Storage at -80 centigrade, Avoid repeated freeze-thaw cycles.
Concentration : 0.117 µg/µl
Gene Name : PRKCH protein kinase C, eta [ Homo sapiens ]
Official Symbol : PRKCH
Synonyms : PKCL; PKC-L; PRKCL; nPKC-eta; protein kinase C eta type
Gene ID : 5583
mRNA Refseq : NM_006255
Protein Refseq : NP_006246
MIM : 605437
UniProt ID : P24723
Chromosome Location : 14q23.1
Pathway : Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; Endothelins, organism-specific biosystem
Function : ATP binding; Ral GTPase binding; calcium-independent protein kinase C activity

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