Recombinant Human GFAP protein, His-tagged
Cat.No. : | GFAP-19H |
Product Overview : | Recombinant Human GFAP (Leu292-Met432) fussed with His tag at N-terminal was expressed in E. coli. |
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Description : | Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament (IF) protein which belongs to the intermediate filament family. GFAP is expressed in numerous cell types of the central nervous system (CNS), ependymal cells and phosphorylated by PKN1. GFAP, a class-III intermediate filament, is a cell-specific marker during the development of the central nervous system and distinguishes astrocytes from other glial cells. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells but its exact function remains poorly understood. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.25 |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMLTCD LESLRGTNESLERQMREQEERHVRE AASYQEALARLEEEG QSLKDEMARHLQEYQDLLNVKLALD IEIATYRKLLEGEENRITIPVQTFS NLQIRETSLDTKSVS EGHLKRNIVVKTVEMRDGEVIKESK QEHKDVM |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | GFAP glial fibrillary acidic protein [ Homo sapiens ] |
Official Symbol : | GFAP |
Synonyms : | ALXDRD; glial fibrillary acidic protein |
Gene ID : | 2670 |
mRNA Refseq : | NM_002055 |
Protein Refseq : | NP_002046 |
MIM : | 137780 |
UniProt ID : | P14136 |
Chromosome Location : | 17q21 |
Pathway : | Neural Crest Differentiation, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; Signal Transduction, organism-specific biosystem |
Function : | integrin binding; kinase binding; protein binding |
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◆ Native Protein | ||
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◆ Lysates | ||
GFAP-5955HCL | Recombinant Human GFAP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGFAP is crucial for maintaining the structure and function of astrocytes in the CNS.
GFAP is used as a biomarker to assess astrocyte activation and neural damage.
It forms intermediate filaments, providing mechanical support and stability to astrocytes.
It plays a protective role, participating in the glial scar formation post-injury.
Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.
Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.
Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.
Customer Reviews (3)
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