Recombinant Human ANXA1 protein

• Cat.No.: ANXA1-9159H
• Product Overview: Recombinant Human ANXA1 (1-346aa) was expressed in E. coli.

Specification

• Description: Annexin A1, also known as Lipocortin I, belongs to a family of Ca(2+)-dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. It promotes membrane fusion and is also involved in exocytosis. Since Annexin A1 has phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity, this protein may have potential anti-inflammatory activity. The detection of this protein by immunocytochemical means reportedly provides a simple, highly sensitive and specific assay for diagnosis of hairy cell leukemia.
• Source: E. coli
• Species: Human
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 1mM DTT, 10% glycerol.
• Molecular Mass: 38.7 kDa (346aa), confirmed by MALDI-TOF.
• AA Sequence: MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGKPLDETLKKAL TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNALLSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK VLDLELKGDI EKCLTAIVKCATSKPAFFAE KLHQAMKGVG TRHKALIRIM VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: ANXA1 annexin A1 [ Homo sapiens ]
• Official Symbol: ANXA1
• Synonyms: ANX1; LPC1; annexin A1; annexin I (lipocortin I); annexin-1; calpactin II; calpactin-2; chromobindin-9; phospholipase A2 inhibitory protein
• Gene ID: 301
• mRNA Refseq: NM_000700
• Protein Refseq: NP_000691
• MIM: 151690
• UniProt ID: P04083
• Chromosome Location: 9q21.13
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: annealing helicase activity; calcium ion binding; calcium-dependent phospholipid binding