Recombinant Human LRP1 protein, Fc-tagged


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Recombinant Human LRP1 protein, Fc-tagged

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Cat.No. : LRP1-653H
Product Overview : Recombinant Human LRP1 Cluster III(Ser2522 - Ile2941) fussed with Fc of Human IgG1 (Pro100 - Lys330) at C-terminal was expressed in CHO.
Description : LDL receptor­related protein 1 (LRP­1), also known as CD91 and the α2­macroglobulin receptor, is a type I transmembrane protein in the LDL receptor superfamily. It is expressed on neurons, hepatocytes, adipocytes, vascular smooth muscle cells, fibroblasts, keratinocytes, macrophages, and megakaryocytes. LRP­1 is important for the clearance of a large number of circulating molecules involved in fatty acid metabolism and the inhibition of serine proteases. LRP­1 also associates, or through intracellular scaffold proteins, with other membrane associated proteins on the same cell. This allows LRP­1 to modulate the activity or internalization of PDGFRβ, NMDA receptor subunits, TGF­β receptors, Frizzled­1, various integrins, and the prion proteinPrPC. Human LRP 1 is N glycosylated and sialylated, and cleaved in the Golgi to produce an 85 kDa transmembrane beta chain, and a 515 kDa alpha chain. Both associate noncovalently, with the beta chain remaining completely extracellular. The alpha chain of LRP 1 contains 31 LDLR class A repeats, 34 LDLR class B repeats, and 22 EGF­like repeats. The LDLR domains are clustered in four regions throughout the protein. Cluster II (aa 786 ­ 1165) contains one EGF­like and eight LDLR class A repeats. Cluster II contains binding sites for Apolipoprotein E, LPL, LRPAP/RAP, alpha 2 Macroglobulin, Coagulation Factor VIII light chain, Lactoferrin, PAI­1, tPA­PAI­1 complexes, Pro­uPA, and TFPI. Within this region, human LRP­1 shares 99% aa sequence identity with mouse and rat LRP­1. A shed soluble form of LRP­1 circulates in the serum and retains ligand binding properties.
Source : CHO
Species : Human
Tag : Fc
Predicted N Terminal : Ser2522
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.When recombinant human (rh) LRP-1 Cluster III Fc Chimera is immobilized at 50 ng/mL (100 µL/well), the concentration of rhLRPAP that produces 50% of the optimal binding response is found to be approximately 1 - 5 ng/mL.
Molecular Mass : Predicted Molecular Mass:72.8 kDa (monomer);SDS-PAGE:115-130 kDa, reducing conditions.
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Stability : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 500 µg/mL in PBS.
Gene Name : LRP1 low density lipoprotein receptor-related protein 1 [ Homo sapiens ]
Official Symbol : LRP1
Synonyms : APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; prolow-density lipoprotein receptor-related protein 1; LRP-1; TbetaR-V/LRP-1/IGFBP-3 receptor; alpha-2-macroglobulin receptor; apolipoprotein E receptor; type V tgf-beta receptor
Gene ID : 4035
mRNA Refseq : NM_002332
Protein Refseq : NP_002323
MIM : 107770
UniProt ID : Q07954
Chromosome Location : 12q13.3
Pathway : Alzheimer's disease, organism-specific biosystem; Alzheimer's disease, conserved biosystem; Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem
Function : apolipoprotein binding; apolipoprotein binding; calcium ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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