Recombinant Human WEE1 protein, MYC/DDK-tagged

• Cat.No.: WEE1-36H
• Product Overview: Recombinant Human WEE1, transcript variant 1, fussed with MYC/DDK at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: WEE1 WEE1 G2 checkpoint kinase [ Homo sapiens ]
• Official Symbol: WEE1
• Synonyms: WEE1A; WEE1hu; wee1-like protein kinase; WEE1 homolog; WEE1+ homolog; wee1A kinase
• Gene ID: 7465
• mRNA Refseq: NM_003390
• Protein Refseq: NP_003381
• MIM: 193525
• UniProt ID: P30291
• Chromosome Location: 11p15.4
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle - G2/M transition, conserved biosystem
• Function: ATP binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity