Recombinant Human PARG protein, His-tagged PARG-31H

Recombinant Human PARG protein, His-tagged

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Recombinant Human PARG protein, His-tagged

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Cat.No. : PARG-31H
Product Overview : Recombinant Human PARG fussed with His tag was expressed in Sf21 cells.
Description : Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
Source : Insect cells
Species : Human
Tag : His
Form : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
Bio-activity : ~100ng is required for poly(ADP-ribose) degradation assays.
Purity : ≥95% (SDS-PAGE)
Notes : After opening, prepare aliquots and store at -80 centigrade. Avoid freeze/thaw cycles.
Stability : Stable for at least 6 months after receipt when stored at -80 centigrade.
Storage : Short Term Storage: -20 centigrade;Long Term Storage: -80 centigrade.
Concentration : Lot dependent (0.2-1.5mg/ml)
Publication : A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation
Gene Name : PARG poly (ADP-ribose) glycohydrolase [ Homo sapiens ]
Official Symbol : PARG
Synonyms : PARG99; poly(ADP-ribose) glycohydrolase; mitochondrial poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform
Gene ID : 850
mRNA Refseq : NM_003631
Protein Refseq : NP_003622
MIM : 603501
UniProt ID : Q86W56
Chromosome Location : 10q11.23
Pathway : Base Excision Repair, organism-specific biosystem; DNA Repair, organism-specific biosystem; POLB-Dependent Long Patch Base Excision Repair, organism-specific biosystem
Function : poly(ADP-ribose) glycohydrolase activity

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