"TNFRSF11A" Related Products

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Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated

Cat.No.: TNFRSF11A-663H
Product Overview: The recombinant human RANK-Fc fusion is expressed as a 411 amino acid protein consisting of Ile30 - Pro212 region of RANK (UniProt accession #Q9Y6Q6) and a C-terminal Fc from human IgG1, which exists as a dimer/tetramer/oligomer under non-reducing conditions.
Source: Human cells
Species: Human
Tag: Fc
Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity: Binds to its ligand human RANKL and inhibits RANKL-induced signaling activity including osteoclast differentiation in mouse monocyte/macrophage cells RAW 264.7.
Molecular Mass: Calculated molecular mass (kDa): 45.7; Estimated by SDS-PAGE under reducing condition (kDa): ~55
Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity: >95% judged by SDS-PAGE under reducing condition
Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name: TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator [ Homo sapiens ]
Official Symbol: TNFRSF11A
Synonyms: TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily member 11A; CD265; RANK; receptor activator of NF-KB; osteoclast differentiation factor receptor; receptor activator of nuclear factor-kappa B; loss of heterozygosity, 18, chromosomal region 1; FEO; OFE; ODFR; OSTS; PDB2; OPTB7; TRANCER; LOH18CR1;
Gene ID: 8792
mRNA Refseq: NM_003839
Protein Refseq: NP_003830
MIM: 603499
UniProt ID: Q9Y6Q6
Chromosome Location: 18q22.1
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function: cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity;

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