Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated TNFRSF11A-663H

Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated

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Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated

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Cat.No. : TNFRSF11A-663H
Product Overview : The recombinant human RANK-Fc fusion is expressed as a 411 amino acid protein consisting of Ile30 - Pro212 region of RANK (UniProt accession #Q9Y6Q6) and a C-terminal Fc from human IgG1, which exists as a dimer/tetramer/oligomer under non-reducing conditions.
Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its ligand human RANKL and inhibits RANKL-induced signaling activity including osteoclast differentiation in mouse monocyte/macrophage cells RAW 264.7.
Molecular Mass : Calculated molecular mass (kDa): 45.7; Estimated by SDS-PAGE under reducing condition (kDa): ~55
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator [ Homo sapiens ]
Official Symbol : TNFRSF11A
Synonyms : TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily member 11A; CD265; RANK; receptor activator of NF-KB; osteoclast differentiation factor receptor; receptor activator of nuclear factor-kappa B; loss of heterozygosity, 18, chromosomal region 1; FEO; OFE; ODFR; OSTS; PDB2; OPTB7; TRANCER; LOH18CR1;
Gene ID : 8792
mRNA Refseq : NM_003839
Protein Refseq : NP_003830
MIM : 603499
UniProt ID : Q9Y6Q6
Chromosome Location : 18q22.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Osteoclast Signaling, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function : cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity;

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