Active Recombinant Human HLA-DRB1, Fc-tagged
Cat.No. : | HLA-DRB1-713H |
Product Overview : | The recombinant human VNN2-Fc fusion is expressed as a 697 amino acid protein consisting of Gln23 - Ser492 region of VNN2 (Uniprot Accession #O95498) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions. |
- Specification
- Gene Information
- Related Products
Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). |
Bio-activity : | VNN2 hydrolyzes D-pantetheine and releases cysteamine. |
Molecular Mass : | Calculated molecular mass (kDa): 78.7; Estimated by SDS-PAGE under reducing condition (kDa): 80-85 |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >95% judged by SDS-PAGE under reducing condition. |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [ Homo sapiens ] |
Official Symbol : | HLA-DRB1 |
Synonyms : | HLA-DRB1; major histocompatibility complex, class II, DR beta 1; HLA DR1B; DW2.2/DR2.2; MHC class II antigen; lymphocyte antigen DRB1; MHC class II HLA-DRw10-beta; human leucocyte antigen DRB1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; HLA class II histocompatibility antigen, DR-1 beta chain; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; FLJ75017; FLJ76359; |
Gene ID : | 3123 |
mRNA Refseq : | NM_001243965 |
Protein Refseq : | NP_001230894 |
MIM : | 142857 |
UniProt ID : | P01911 |
Chromosome Location : | 6p21.3 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; |
Function : | MHC class II receptor activity; MHC class II receptor activity; |
Products Types
◆ Recombinant Protein | ||
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HLA-DRB1-358M | Recombinant Mouse HLA-DRB1 Protein, His-tagged | +Inquiry |
HLA-DRB1-1240H | Recombinant Human HLA-DRB1 Protein, His-SUMO/MYC-tagged | +Inquiry |
HLA-DRB1-5089H | Recombinant Human HLA-DRB1, His-tagged | +Inquiry |
HLA-DRB1-4303H | Recombinant Human HLA-DRB1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
HLA-DRB1-797HCL | Recombinant Human HLA-DRB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionHLA-DRB1 alleles are linked to susceptibility and progression of various diseases.
Certain HLA-DRB1 alleles are associated with a higher risk of autoimmune diseases.
Variability in HLA-DRB1 can affect transplant success, with mismatches potentially leading to rejection.
Its expression is tightly controlled, influenced by cytokines and immune signals.
It binds peptides from extracellular proteins, presenting them on the cell surface for T cell recognition.
HLA-DRB1 is crucial for immune responses, presenting peptides to CD4+ T cells.
Therapeutic strategies might involve modulating HLA-DRB1 expression or function in autoimmune diseases or transplantation.
Customer Reviews (3)
Write a reviewConsistently good quality.
Great product, fast shipping.
Excellent quality, very pure.
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