Recombinant Mouse Cd274, Fc-tagged, Biotinylated Cd274-721M

Recombinant Mouse Cd274, Fc-tagged, Biotinylated


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Recombinant Mouse Cd274, Fc-tagged, Biotinylated

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Cat.No. : Cd274-721M
Product Overview : The recombinant mouse PD-L1/CD274 ECD is expressed as a 458 amino acid protein consisting of Phe19 - Thr238 region of mouse PD-L1/CD274 (UniProt accession #Q9EP73) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source : Human cells
Species : Mouse
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Binds to its receptor PD-1 and anti-PD-L1 monoclonal antibody. Blocks PD-L1"s binding to its receptor and mediated signaling activity. Shows cross-species binding to human PD-1 and human CD80 in a functional ELISA
Molecular Mass : Calculated molecular mass 51.5 kDa; estimated by SDS-PAGE under reducing condition 60-65 kDa suggesting that the protein is highly glycosylated
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : Cd274 CD274 antigen [ Mus musculus ]
Official Symbol : Cd274
Synonyms : CD274; CD274 antigen; programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1; programmed death ligand 1; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik;
Gene ID : 60533
mRNA Refseq : NM_021893
Protein Refseq : NP_068693
UniProt ID :
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem;
Function : protein binding; receptor activity;

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