Recombinant Human NPR2 protein, GST-tagged

• Cat.No.: NPR2-323H
• Product Overview: Recombinant Human NPR2(1 a.a. - 1023 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 140.5 kDa
• AA Sequence: MALPSLLLLVAALAGGVRPPGARNL TLAVVLPEHNLSYAWAWPRVGPAVA LAVEALGRALPVDLRFVSSELEGAC SEYLAPLSAVDLKLYHDPDLLLGPG CVYPAASVARFASHWRLPLLTAGAV ASGFSAKNDHYRTLVRTGPSAPKLG EFVVTLHGHFNWTARAALLYLDART DDRPHYFTIEGVFEALQGSNLSVQH QVYAREPGGPEQATHFIRANGRIVY ICGPLEMLHEILLQAQRENLTNGDY VFFYLDVFGESLRAGPTRATGRPWQ DNRTREQAQALREAFQTVLVITYRE PPNPEYQEFQNRLLIRAREDFGVEL GPSLMNLIAGCFYDGILLYAEVLNE TIQEGGTREDGLRIVEKMQGRRYHG VTGLVVMDKNNDRETDFVLWAMGDL DSGDFQPAAHYSGAEKQIWWTGRPI PWVKGAPPSDNPPCAFDLDDPSCDK TPLSTLAIVALGTGITFIMFGVSSF LIFRKLMLEKELASMLWRIRWEELQ FGNSERYHKGAGSRLTLSLRGSSYG SLMTAHGKYQIFANTGHFKGNVVAI KHVNKKRIELTRQVLFELKHMRDVQ FNHLTRFIGACIDPPNICIVTEYCP RGSLQGMAFLHNSIISSHGSLKSSN CVVDSRFVLKITDYGLASFRSTAEP DDSHALYAKKLWTAPELLSGNPLPT TGMQKADVYSFGIILQEIALRSGPF YLEGLDLSPKEIVQKVRNGQRPYFR PSIDRTQLNEELVLLMERCWAQDPA ERPDFGQIKGFIRRFNKEGGTSILD NLLLRMEQYANNLEKLVEERTQAYL EEKRKAEALLYQILPHSVAEQLKRG ETVQAEAFDSVTIYFSDIVGFTALS AESTPMQVVTLLNDLYTCFDAIIDN FDVYKVETIGDAYMVVSGLPGRNGQ RHAPEIARMALALLDAVSSFRIRHR PHDQLRLRIGVHTGPVCAGVVGLKM PRYCLFGDTVNTASRMESNGQALKI HVSSTTKDALDELGCFQLELRGDVE MKGKGKMRTYWLLGERKGPPGLL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) [ Homo sapiens ]
• Official Symbol: NPR2
• Synonyms: NPR2; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); acromesomelic dysplasia, Maroteaux type , AMDM, ANPRB, NPRB; atrial natriuretic peptide receptor 2; ANPb; GUCY2B; GC-B; ANP-B; NPR-B; ANPR-B; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B; AMDM; NPRB; ANPRB; GUC2B; NPRBi
• Gene ID: 4882
• mRNA Refseq: NM_003995
• Protein Refseq: NP_003986
• MIM: 108961
• UniProt ID: P20594
• Chromosome Location: 9p21-p12
• Pathway: Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem
• Function: ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; natriuretic peptide receptor activity; nucleotide binding; peptide hormone binding; protein kinase activity; receptor activity; transferase activity, transferring phosphorus-containing groups; transmembrane signaling receptor activity