Active Recombinant Human DPP4 protein, His-tagged
Cat.No. : | DPP4-215H |
Product Overview : | Recombinant Human DPP4(39 a.a. - 766 a.a.) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | In 20 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 8.0 (10% glycerol) |
Bio-activity : | Approximately > 50 Unit/mg. |
Molecular Mass : | 86.4 kDa |
AA Sequence : | ADPRKTYTLTDYLKNTYRLKLYSLR WISDHEYLYKQENNILVFNAEYGNS SVFLENSTFDEFGHSINDYSISPDG QFILLEYNYVKQWRHSYTASYDIYD LNKRQLITEERIPNNTQWVTWSPVG HKLAYVWNNDIYVKIEPNLPSYRIT WTGKEDIIYNGITDWVYEEEVFSAY SALWWSPNGTFLAYAQFNDTEVPLI EYSFYSDESLQYPKTVRVPYPKAGA VNPTVKFFVVNTDSLSSVTNATSIQ ITAPASMLIGDHYLCDVTWATQERI SLQWLRRIQNYSVMDICDYDESSGR WNCLVARQHIEMSTTGWVGRFRPSE PHFTLDGNSFYKIISNEEGYRHICY FQIDKKDCTFITKGTWEVIGIEALT SDYLYYISNEYKGMPGGRNLYKIQL SDYTKVTCLSCELNPERCQYYSVSF SKEAKYYQLRCSGPGLPLYTLHSSV NDKGLRVLEDNSALDKMLQNVQMPS KKLDFIILNETKFWYQMILPPHFDK SKKYPLLLDVYAGPCSQKADTVFRL NWATYLASTENIIVASFDGRGSGYQ GDKIMHAINRRLGTFEVEDQIEAAR QFSKMGFVDNKRIAIWGWSYGGYVT SMVLGSGSGVFKCGIAVAPVSRWEY YDSVYTERYMGLPTPEDNLDHYRNS TVMSRAENFKQVEYLLIHGTADDNV HFQQSAQISKALVDVGVDFQAMWYT DEDHGIASSTAHQHIYTHMSHFIKQ CFSLP-SGRLVPRGSHHHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | > 95% by SDS-PAGE |
Unit Definition : | One unit will hydrolyze 1 umole of p-nitroaniline per minute at pH 8.0 at 37 centigrade using 1mM of Gly-Pro p-nitroanilde as a substrate. |
Applications : | Functional Study; SDS-PAGE |
Storage : | Store at 4 centigrade for 1-2 weeks. For long term storage store at -20 centigrade or -80 centigrade.Aliquot to avoid repeated freezing and thawing. |
Concentration : | 0.5 mg/mL |
Gene Name : | DPP4 dipeptidyl-peptidase 4 [ Homo sapiens ] |
Official Symbol : | DPP4 |
Synonyms : | DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103; |
Gene ID : | 1803 |
mRNA Refseq : | NM_001935 |
Protein Refseq : | NP_001926 |
MIM : | 102720 |
UniProt ID : | P27487 |
Chromosome Location : | 2q23-qter |
Pathway : | Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem; |
Function : | aminopeptidase activity; collagen binding; dipeptidyl-peptidase activity; peptidase activity; peptide binding; protease binding; protein binding; protein homodimerization activity; receptor activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity; |
Products Types
◆ Recombinant Protein | ||
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DPP4-1602R | Recombinant Rat DPP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
DPP4-040H | Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
DPP4-793H | Recombinant Human DPP4 Protein | +Inquiry |
DPP4-2540H | Recombinant Human DPP4 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
DPP4-31H | Active Native Human DPP4 | +Inquiry |
DPP4-197H | Native Human Dipeptidyl Peptidase IV | +Inquiry |
◆ Lysates | ||
DPP4-2979HCL | Recombinant Human DPP4 cell lysate | +Inquiry |
DPP4-733CCL | Recombinant Cynomolgus DPP4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0312 | Dipeptidyl peptidase IV Inhibitor Screening Assay Kit | +Inquiry |
Kit-0313 | DPP IV Immunocapture Activity Assay Kit | +Inquiry |
Kit-0314 | DPP4 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0317 | DPPIV/CD26 Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.
Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.
Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.
DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.
DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.
Customer Reviews (3)
Write a reviewIts purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.
By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.
Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.
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