| Cat. No. : |
RXRA -199H |
| Product Overview : |
The DNA binding domain of RXR(111-228aa) was over expressed in E.coli and purified by using conventional column chromatography techniques (119 aa, 13.6 kDa). |
| Description : |
The retinoid X receptor(RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors(RAR), thyroid hormone receptors(TR), vitamin D receptors and peroxisome proliferators-activated receptors(PPAR). The RXR family includes three difference isoforms ; RXR a, b, g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms(RXR a1, RXR a2). |
| Source : |
Escherichia Coli. |
| Formulation : |
Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM b-Mercaptoethanol. |
| Molecular Weight : |
13.6 kDa (119 aa). |
| Purity : |
> 95% by SDS – PAGE. |
| Concentration : |
1 mg/ml (determined by Bradford assay). |
| Amino acid Sequence : |
MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE |
| Storage : |
Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| PDBrendering based on 1by4. Available structures:1by4, 1dkf, 1dsz, 1fby, 1fm6, 1fm9, 1g1u, 1g5y, 1k74, 1lbd, 1mv9, 1mvc, 1mzn, 1r0n, 1rdt, 1rxr, 1xdk, 1xls, 1xv9, 1xvp, 1ynw, 2acl, 2nll. : |
|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.