Recombinant Human Retinoid X Receptor, Alpha

• Cat.No.: RXRA-199H
• Product Overview: The DNA binding domain of RXR(111-228aa) was over expressed in E.coli and purified by using conventional column chromatography techniques (119 aa, 13.6 kDa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 111-228 a.a.
• Description: The retinoid X receptor(RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors(RAR), thyroid hormone receptors(TR), vitamin D receptors and peroxisome proliferators-activated receptors(PPAR). The RXR family includes three difference isoforms ; RXR a, b, g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms(RXR a1, RXR a2).
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM b-Mercaptoethanol.
• Molecular Weight: 13.6 kDa (119 aa).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Amino acid Sequence: MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: RXRA retinoid X receptor, alpha [ Homo sapiens ]
• Synonyms: RXRA; FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720; NR2B1; OTTHUMP00000022510; Retinoid X receptor alpha; retinoid X receptor, alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor, alpha; Retinoid X receptor alpha (RXR-alpha).
• Gene ID: 6256
• mRNA Refseq: NM_002957
• Protein Refseq: NP_002948
• MIM: 180245
• UniProt ID: P19793
• Chromosome Location: 9q34.3
• Pathway: Adipocytokine signaling pathway; Non-small cell lung cancer; PPAR signaling pathway; Small cell lung cancer; Thyroid cancer.
• Function: ligand-regulated transcription factor activity; metal ion binding; protein binding; retinoid-X receptor activity; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; vitamin D receptor binding; vitamin D response element binding; zinc ion binding.