| Cat. No. : |
RXRA -199H |
| Product Overview : |
The DNA binding domain of RXR(111-228aa) was over expressed in E.coli and purified by using conventional column chromatography techniques (119 aa, 13.6 kDa). |
| Description : |
The retinoid X receptor(RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors(RAR), thyroid hormone receptors(TR), vitamin D receptors and peroxisome proliferators-activated receptors(PPAR). The RXR family includes three difference isoforms ; RXR a, b, g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms(RXR a1, RXR a2). |
| Source : |
Escherichia Coli. |
| Formulation : |
Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 5 mM b-Mercaptoethanol. |
| Molecular Weight : |
13.6 kDa (119 aa). |
| Purity : |
> 95% by SDS – PAGE. |
| Concentration : |
1 mg/ml (determined by Bradford assay). |
| Amino acid Sequence : |
MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE |
| Storage : |
Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| PDBrendering based on 1by4. Available structures:1by4, 1dkf, 1dsz, 1fby, 1fm6, 1fm9, 1g1u, 1g5y, 1k74, 1lbd, 1mv9, 1mvc, 1mzn, 1r0n, 1rdt, 1rxr, 1xdk, 1xls, 1xv9, 1xvp, 1ynw, 2acl, 2nll. : |
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