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Recombinant Human Coagulation Factor VIII, Procoagulant Component

Cat. No.: F8-125H
Product Overview: Recombinant Human F8 lacks central region of B-domain region and is purified by proprietary chromatographic techniques.
Description: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Source: CHO Cells
Molecular Mass: Antihemophilic Facor Human Recombinant produced in CHO is a glycosylated polypeptide chain having a total amino acids of 1438 (170kd) and consisting of two dimer chains 80 kD and 90 kD.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: The protein was lyophilized from a solution containing 50mM histidine, 0.3M NaCl, 5mM CaCl2, 0.02% Tween 80, 20mM sucrose, pH- 6.8.
Purity: Greater than 97.0% as determined by SDS-PAGE.
Solubility: It is recommended to reconstitute the lyophilized Factor-VIII in 1ml sterile 18MΩ-cm H2O, which can then be further diluted to other aqueous solutions.
Biological Activity: The specific activity was found to be 7428IU/mg.
Stability: Lyophilized Factor-VIII although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Factor-VIII should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles
OfficialSymbol: F8
Gene Name: F8 coagulation factor VIII, procoagulant component [ Homo sapiens ]
Synonyms: F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; Factor VIIIF8B; hemophilia A; Antihemophilic factor; Procoagulant component; coagulation factor VIII; coagulation factor VIIIc; coagulation factor VIII; OTTHUMP00000061446; OTTHUMP00000196174; Coagulation factor VIII; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain
Gene ID: 2157
mRNA Refseq: NM_000132
Protein Refseq: NP_000123
MIM: 300841
UniProt ID: P00451
Chromosome Location: Xq28
Pathway: Complement and coagulation cascades; Hemostasis
Function: copper ion binding; oxidoreductase activity; protein binding

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