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Recombinant Human LYVE1

Cat. No.: LYVE1-156H
Product Overview: Recombinant Human Lymphatic Vessel Endothelial Hyluronan Receptor-1 protein expressed inE.coliencodes amino acids 243-323 and has a molecular mass of 36 kDa.
Description: The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells. However, LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumor metastasis, LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumours exploit lymphatic vessels for metastasis.
Source: Recombinant Human LYVE-1 protein encoding 243-323 a.a expressed inE.coli.
Formulation: Recombinant Human LYVE-1 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Application And Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting.
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 36kDa.
Storage & Stability: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name: LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens ]
Synonyms: lymphatic vessel endothelial hyaluronan receptor 1; HAR; XLKD1; LYVE-1; CRSBP-1; LYVE1; hyaluronic acid receptor; extracellular link domain containing 1; extracellular link domain-containing 1; cell surface retention sequence binding protein-1; CRSBP1; Cell surface retention sequence-binding protein 1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
Gene ID: 10894
mRNA Refseq: NM_006691
Protein Refseq: NP_006682
MIM: 605702
UniProt ID: Q9Y5Y7
Function: transmembrane receptor activity; hyaluronic acid binding; binding

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