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Recombinant Human RCAN Family Member 3

Cat. No.: RCAN3-115H
Product Overview: Recombinant Human DSC1 Isoform-b produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 117 amino acids and has a molecular mass of 13 kDa.
Description: DSC1 encoded by a gene located in the human chromosome 21, interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. DSC1 is located in the minimal candidate region for the Down syndrome phenotype, and is over expressed in the brain of Down syndrome fetuses. Chronic over expression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development.
Source: Escherichia Coli.
Amino Acid Sequence: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRR PK PKIIQTRRPE YTPIHLS.
Physical Appearance: Sterile Filtered colorless solution.
Formulation: The protein solution (1mg/ml) cotains 20mM Tris-HCl pH-7.5, 100mM NaCl and 1mM DTT.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability: SNAP25 although stable 14°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: RCAN3 RCAN family member 3 [ Homo sapiens ]
Synonyms: RCAN3; RCAN family member 3; RCN3; MCIP3; hRCN3; DSCR1L2;Calcipressin-3;Regulator of calcineurin 3; Down syndrome candidate region 1-like protein 2; Myocyte-enriched calcineurin-interacting protein 3; OTTHUMP00000003336; Down syndrome candidate region 1-like 2; Down syndrome critical region gene 1-like 2; Myocyte-enriched calcineurin-interacting protein 3; RCAN family member 3; Regulator of calcineurin 3
Gene ID: 11123
mRNA Refseq: NM_013441
Protein Refseq: NP_038469
UniProt ID: Q9UKA8
Chromosome Location: 1p35.3-p33
MIM: 605860
Function: RNA binding; troponin I binding

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