Recombinant Human Tumor Protein P53


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Recombinant Human Tumor Protein P53

TP53 Related Products

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Cat. No. : TP53-170H
Product Overview : Recombinant Human TP53 protein expressed inE.coliencodesfull length amino acids and has a molecular mass of 43.7 kDa.
Description : p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Source : E.coli.
Formulation : 5µg/5µl purified human p53 in 20mM Tris-Acetate, pH 8, 0.6M Nacl and 50% Glycerol.
Application : • P53 is an excellent substrate for kinase assays; • It can be used as a reagent for development of DNA based binding Assay.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Activity : Active in DNA binding assays.
Storage & Stability : For long term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : TP53 tumor protein p53 [ Homo sapiens ]
Synonyms : TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53
Gene ID : 7157
mRNA Refseq : NM_000546
Protein Refseq : NP_000537
MIM : 191170
UniProt ID : P04637
Chromosome Location : 17p13.1
Pathway : Amyotrophic lateral sclerosis (ALS); Apoptosis; Basal cell carcinoma; Bladder cancer; Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; Glioma; Huntington"s disease; MAPK signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway; p53 signaling pathway; Cell Cycle Checkpoints
Function : ATP binding; DNA strand annealing activity; chaperone binding; chromatin binding; copper ion binding; enzyme binding; metal ion binding; promoter binding; protein N-terminus binding; protein heterodimerization activity; transcription factor activity; transcription factor binding; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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