"TP53" Related Products


Recombinant Human Tumor Protein P53

Cat. No. : TP53-170H
Product Overview : Recombinant Human TP53 protein expressed inE.coliencodesfull length amino acids and has a molecular mass of 43.7 kDa.
Description : p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Source : E.coli.
Formulation : 5µg/5µl purified human p53 in 20mM Tris-Acetate, pH 8, 0.6M Nacl and 50% Glycerol.
Application : • P53 is an excellent substrate for kinase assays; • It can be used as a reagent for development of DNA based binding Assay.
Purity : Greater than 95.0% as determined by SDS-PAGE.
Activity : Active in DNA binding assays.
Storage & Stability : For long term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : TP53 tumor protein p53 [ Homo sapiens ]
Synonyms : TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53
Gene ID : 7157
mRNA Refseq : NM_000546
Protein Refseq : NP_000537
MIM : 191170
UniProt ID : P04637
Chromosome Location : 17p13.1
Pathway : Amyotrophic lateral sclerosis (ALS); Apoptosis; Basal cell carcinoma; Bladder cancer; Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; Glioma; Huntington"s disease; MAPK signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway; p53 signaling pathway; Cell Cycle Checkpoints
Function : ATP binding; DNA strand annealing activity; chaperone binding; chromatin binding; copper ion binding; enzyme binding; metal ion binding; promoter binding; protein N-terminus binding; protein heterodimerization activity; transcription factor activity; transcription factor binding; zinc ion binding

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