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Recombinant Human tripartite motif-containing 21

Cat.No. : TRIM21-196H
Product Overview : Recombinant Human RO-52 produced inE.Coliis a single, non-glycosylated, polypeptide chain. The protein has a molecular mass of 52kDa. The RO-52 is purified by proprietary chromatographic techniques.
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Cat. No. : TRIM21-196H
Description : Calreticulin is a multifunctional protein that binds Ca2+ ions (a second messenger molecule in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.
Source : Escherichia Coli.
Amino Acid Sequence : MASAARLTMMWEEVTCPICLDPFVE PVSIECGHSFCQECISQVGKGGGSV CAVCRQRFLLKNLRPNRQLANMVNN LKEISQEAREGTQGERCAVHGERLH LFCEKDGKALCWVCAQSRKHRDHAM VPLEEAAQEYQEKLQVALGELRRKQ ELAEKLEVEIAIKRADWKKTVETQK SRIHAEFVQQKNFLVEEEQRQLQEL EKDEREQLRILGEKEAKLAQQSQAL QELISELDRRCHSSALELLQEVIIV LERSESWNLKDLDITSPELRSVCHV PGLKKMLRTCAVHITLDPDTANPWL ILSEDRRQVRLGDTQQSIPGNEERF DSYPMVLGAQHFHSGKHYWEVDVTG KEAWDLGVCRDSVRRKGHFLLSSKS GFWTIWLWNKQKYEAGTYPQTPLHL QVPPCQVGIFLDYEAGMVSFYNITD HGSLIYSFSECAFTGPLRPFFSPGF NDGGKNTAPLTLCPLNIGSQGSTDY .
Physical Appearance : Sterile Filtered clear solution.
Formulation : The protein solution (1mg/ml) contains 6M Urea, 500mM NaCl and 10mM Tris pH8.0.
Purity : Greater than 90.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Protein Content : Protein quantitation was carried out by using 0.25 -2.0 mg/ml Bradford assay vs. BSA.
Western Blot : Strongly reactive with human anti RO/SS-A.
Stability : Lyophilized RO-52 although stable at 4°Cfor 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name : TRIM21 tripartite motif-containing 21 [ Homo sapiens ]
Synonyms : TRIM21; tripartite motif-containing 21; SSA; RO52; SSA1; RNF81; SSA1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro);52 kDa Ro protein;Sjoegren syndrome type A antigen; SS-A; Ro(SS-A); 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Tripartite motif-containing protein 21; RING finger protein 81; TRIM21 ; Ro(SS-A); SS-A; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1 (52kDa, ribonucleoproteinautoantigen SS-A/Ro); tripartite motif protein 21; Tripartite motif-containing 21
Gene ID : 6737
mRNA Refseq : NM_003141
Protein Refseq : NP_003132
MIM : 1099092
UniProt ID : P19474
Chromosome Location : 11p15.5-p15.3
Pathway : Systemic lupus erythematosus
Function : DNA binding;RNA binding;metal ion binding;protein binding;zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific viral infections that TRIM21 is particularly effective against? 10/31/2022

TRIM21 has demonstrated efficacy against a broad range of viruses, including but not limited to influenza, herpes simplex virus, and adenovirus.

How does TRIM21 function in the immune system? 11/14/2020

TRIM21 acts as an intracellular antibody receptor, binding to antibodies that have attached to viruses inside the cell. This binding triggers a process that leads to the destruction of the virus.

What are the potential clinical applications of TRIM21? 02/28/2019

TRIM21 has promising applications in various clinical settings, particularly in the development of therapies for viral infections and autoimmune diseases.

How does TRIM21 contribute to the treatment of autoimmune diseases? 05/15/2017

TRIM21's role in regulating immune responses makes it a potential target for therapies aimed at modulating the immune system in autoimmune diseases.

Can TRIM21 be used in antiviral therapies? 06/05/2016

Yes, TRIM21's ability to target and degrade antibody-bound viruses makes it a potential candidate for antiviral therapies.

Customer Reviews (3)

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08/13/2022

    They can provide fast and efficient delivery services, minimizing any potential delays and allowing researchers to proceed with their studies in a timely manner.

    12/30/2020

      The manufacturer can provide researchers with a high-quality, purified form of TRIM21 protein, ensuring its integrity and functionality for experimental use.

      10/11/2017

        A manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.

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