"COX17" Related Products

Expand

Recombinant Human COX17 (S. cerevisiae)

Cat. No.: COX17-448H
Product Overview: Recombinant Human full length recombinant Cox17 (Cytochrome C oxidase assembly protein) cloned from Human cDNA was expressed inE.coli. It consists of the full length apo-Human Cox172S-S with the addition of an GSFT N-terminal sequence. MW = 7.3 kDa.
Description: Cytochrome c oxidase copper chaperone is an enzyme that in humans is encoded by the COX17 gene. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Source: Escherichia Coli.
Purity: > 95% by SDS-PAGE. The protein was observed as a single band. Cysteine alkilation with AMS monitored by MALDI-TOF show that the protein is obtained in the 2S-S form while the cysteines of the binding site are reduced.
Supplied As: 1.0mg at 1.0mg/ml in 50mM KH2PO4/K2HPO4 pH7, 1mM DTT (Dithiothreitol). The concentration is estimated by Bradford assay.
Characteristics: Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 1mM.
Storage: -20°C. The protein is stable at 4°C for at least 2 weeks and at 25°C for at least several hours. After initial defrost, aliquot protein into individual tubes and refreeze at -20°C. Avoid repeated freeze/defrost cycles.
Gene Name: COX17 COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) [ Homo sapiens ]
Synonyms: COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); X17 homolog, cytochrome c oxidase assembly protein; COX17 (yeast) homolog, cytochrome c oxidase assembly protein; COX17 homolog, cytochrome c oxidase assembly protein (yeast); COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae); COX17 homolog, cytochrome c oxidase assembly protein; Cytochrome c oxidase copper chaperone; human homolog of yeast mitochondrial copper recruitment MGC104397; MGC117386
Gene ID: 1006
mRNA Refseq: NM_005694
Protein Refseq: NP_005685
MIM: 604813
UniProt ID: Q14061
Chromosome Location: 3q13.33
Pathway: Metabolic pathways; Oxidative phosphorylation
Function: copper chaperone activity; metal ion bindin

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.