Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera FLT3-140H

Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera

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Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera

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Cat. No. : FLT3-140H
Product Overview : Recombinant Human fms-related tyrosine kinase 3 encoding the signal peptide and extracellular domain of human Flt-3 (aa 1-540) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.
Description : Fms-like tyrosine kinase 3 (Flt-3) and its cognate ligand, Flt-3 Ligand (Flt-3L), are essential growth factors involved in the survival and differentiation of hematopoietic progenitor and stem cells, specifically the development of NK cells, pre-B and pre-T cells, monocytes/macrophages and dendritic cells.
Source : Human 293 cells.
Amino Acid Sequence : NQDLPVIKCVLINHK NNDSSVGKSSSYPMV SESPEDLGCALRPQS SGTVYEAAAVEVDVS ASITLQVLVDAPGNI SCLWVFKHSSLNCQP HFDLQNRGVVSMVIL KMTETQAGEYLLFIQ SEATNYTILFTVSIR NTLLYTLRRPYFRKM ENQDALVCISESVPE PIVEWVLCDSQGESC KEESPAVVKKEEKVL HELFGTDIRCCARNE LGRECTRLFTIDLNQ TPQTTLPQLFLKVGE PLWIRCKAVHVNHGF GLTWELENKALEEGN YFEMSTYSTNRTMIR ILFAFVSSVARNDTG YYTCSSSKHPSQSAL VTIVEKGFINATNSS EDYEIDQYEEFCFSV RFKAYPQIRCTWTFS RKSFPCEQKGLDNGY SISKFCNHKHQPGEY IFHAENDDAQFTKMF TLNIRRKPQVLAEAS ASQASCFSDGYPLPS WTWKKCSDKSPNCTE EITEGVWNRKANRKV FGQWVSSSTLNMSEA IKGFLVKCCAYNSLG TSCETILLNSPGPFP FIQDRIPKVDKKVEP KSCDKTHTCPPCPAP ELLGGPSVFLFPPKP KDTLMISRTPEVTCV VVDVSHEDPEVKFNW YVDGVEVHNAKTKPR EEQYNSTYRVVSVLT VLHQDWLNGKEYKCR VSNKALPAPIEKTIS KAKGQPREPQVYTLP PSRDELTKNQVSLTC LVKGFYPSDIAVEWE SNGQPENNYKTTPPV LDSDGSFFLYSKLTV DKSRWQQGNVFSCSV MHEALHNHYTQKSLS LSPGK.
Molecular Mass : Flt-3-Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI : Flt-3-Fc Chimera separates into a number of isoforms with a pI between 5.1 and 6.8 in 2D PAGE due to post-translational modifications, in particular glycosylation.
% Carbohydrate : Purified Flt-3-Fc Chimera consists of 15-35% carbohydrate by weight.
Glycosylation : Flt-3-Fc Chimera has N-linked and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Activity : The ED50 of Flt-3-Fc Chimera is typically 1.0 -2.0 ng/ml as measured by its ability to neutralize Flt-3 mediated proliferation of the OCI/AML5 human leukemia cell line.
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Synonyms : FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetal liver kinase 2
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
UniProt ID : P36888
Chromosome Location : 13q12
MIM : 136351
Pathway : ute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
Function : ATP binding; nucleotide binding; osphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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