Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera

Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera

FLT3 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : FLT3-140H
Product Overview : Recombinant Human fms-related tyrosine kinase 3 encoding the signal peptide and extracellular domain of human Flt-3 (aa 1-540) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.
Description : Fms-like tyrosine kinase 3 (Flt-3) and its cognate ligand, Flt-3 Ligand (Flt-3L), are essential growth factors involved in the survival and differentiation of hematopoietic progenitor and stem cells, specifically the development of NK cells, pre-B and pre-T cells, monocytes/macrophages and dendritic cells.
Source : Human 293 cells.
Amino Acid Sequence : NQDLPVIKCV LINHKNNDSS VGKSSSYPMV SESPEDLGCA LRPQSSGTVY EAAAVEVDVS ASITLQVLVD APGNISCLWV FKHSSLNCQP HFDLQNRGVV SMVILKMTET QAGEYLLFIQ SEATNYTILF TVSIRNTLLY TLRRPYFRKM ENQDALVCIS ESVPEPIVEW VLCDSQGESC KEESPAVVKK EEKVLHELFG TDIRCCARNE LGRECTRLFT IDLNQTPQTT LPQLFLKVGE PLWIRCKAVH VNHGFGLTWE LENKALEEGN YFEMSTYSTN RTMIRILFAF VSSVARNDTG YYTCSSSKHP SQSALVTIVE KGFINATNSS EDYEIDQYEE FCFSVRFKAY PQIRCTWTFS RKSFPCEQKG LDNGYSISKF CNHKHQPGEY IFHAENDDAQ FTKMFTLNIR RKPQVLAEAS ASQASCFSDG YPLPSWTWKK CSDKSPNCTE EITEGVWNRK ANRKVFGQWV SSSTLNMSEA IKGFLVKCCA YNSLGTSCET ILLNSPGPFP FIQDRIPKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCR VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK.
Molecular Mass : Flt-3-Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation.
pI : Flt-3-Fc Chimera separates into a number of isoforms with a pI between 5.1 and 6.8 in 2D PAGE due to post-translational modifications, in particular glycosylation.
% Carbohydrate : Purified Flt-3-Fc Chimera consists of 15-35% carbohydrate by weight.
Glycosylation : Flt-3-Fc Chimera has N-linked and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
Activity : The ED50 of Flt-3-Fc Chimera is typically 1.0 -2.0 ng/ml as measured by its ability to neutralize Flt-3 mediated proliferation of the OCI/AML5 human leukemia cell line.
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Synonyms : FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokine receptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetal liver kinase 2
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
UniProt ID : P36888
Chromosome Location : 13q12
MIM : 136351
Pathway : ute myeloid leukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
Function : ATP binding; nucleotide binding; osphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Online Inquiry


  • Note: There will be extra charge for optional service!

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy