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Recombinant Human NGFR, 222aa, Fc Chimera

Cat. No.: NGFR-453H
Product Overview: Recombinat human Nerve growth factor receptor was fused to the Fc region of human IgG1 (aa 93-330). It was expressed in modifiedhuman 293 cells.
Description: Nerve growth factor receptor (NGFR), also known as p75NTR or CD271 antigen, is a low affinity NGF receptor primarily responsible for modulating the affinity and activity of tyrosine kinases that promote neuronal survival. Ligand binding by neurotrophins, including beta NGF, brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-5 (NT4/5), to the NGF R can promote either survival or apoptosis of neurons. NGF receptors such as TrkA, B and C, can associate with NGF R to stimulate higher affinity ligand binding, although on its own NGF R binds to all neutrophins within equal affinity. Neurotrophin-NGFR signaling mediates conditions such as pain, depression, obesity, nerve regeneration disorders, learning and memory. Additionally, NGF R is thought to play a role in neuronal death that occurs in disorders of the CNS such as Alzheimer's disease.
Source: human 293 cells.
Molecular Mass: NGFR(222aa) - Fc Chimera migrates as a broad band between 75 and 100 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with unmodified NGFR(222aa) – Fc Chimera that has a predicted molecular mass of 50.8 kDa.
pI: NGFR(222aa) - Fc Chimera separates into a number of isoforms with a pI between 4.0 and 6.0 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified NGFR(222aa) – Fc Chimera that has a predicted pI of 4.89.
% Carbohydrate: NGFR (222aa) - Fc Chimera consists of 30-50% carbohydrate by weight.
Glycosylation: NGFR (222aa) - Fc Chimera contains N-linked and O-linked oligosaccharides.
Purity: >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation: When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage: Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C.
Gene Name: NGFR nerve growth factor receptor (TNFR superfamily, member 16) [ Homo sapiens ]
Synonyms: nerve growth factor receptor (TNFR superfamily, member 16); CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR; nerve growth factor receptor; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; CD271 antigen; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD
Gene ID: 4804
mRNA Refseq: NM_002507
Protein Refseq: NP_002498
MIM: 162010
UniProt ID: P08138
Chromosome Location: 17q21-q22
Pathway: Cytokine-cytokine receptor interaction; Neurotrophin signaling pathway; Signalling by NGF
Function: catalytic activity; death receptor activity; nerve growth factor binding; neurotrophin receptor activity; protein binding

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