Recombinant Human Spastic Paraplegia 21, His-tagged SPG21-501H

Cat. No.:	SPG21-501H
Product Overview:	Recombinant human SPG21 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW=37.1kDa.
Description:	Spastic paraplegia 21(SPG21), also known as Maspardin, binds to the hydrophobic C-terminal amino acids of CD4 and may play a role as a negative regulatory factor in CD4-depenent T-cell activation. This protein is widely expressed in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Mutations in SPG21 cause Mast syndrome, an autosomal-recessive complicated form of hereditary spastic paraplegia characterized by dementia, thin corpus callosum and white matter abnormalities.
Source:	E. Coli.
Amino Acid Sequence:	MGSSHHHHHH SSGLVPRGSH MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS LGISQEEQ.
From:	Liquid. In 20mM Tris-HCl buffer (pH8.0).
Purity:	>95% by SDS–PAGE.
Concentration:	1mg/ml (determined by Bradford assay).
Endotoxin Level:	<1.0 EU per 1μg of protein (determined by LAL method).
Storage:	Can be stored at +4°C short term (1-2weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

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Gene Name:	SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) [ Homo sapiens ]
Synonyms:	SPG21; spastic paraplegia 21 (autosomal recessive, Mast syndrome); MAST; ACP33; GL010; BM-019; MASPARDIN; SPG21; maspardin; Maspardin;Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Acid cluster protein 33; spastic paraplegia 21
Gene ID:	51324
mRNA Refseq:	NM_001127889
Protein Refseq:	NP_001121361
MIM:	608181
UniProt ID:	Q9NZD8
Chromosome Location:	15q21-q22
Function:	CD4 receptor binding