Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain


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Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain

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Cat. No. : SPTAN1-468C
Product Overview : Recombinant chickenα-Spectrin domain SH3 (Spectrin, non-erythroid alpha chain, Fodrin alpha chain) cloned from cDNA from chicken was expressed inE. coli. It consists of the soluble SH3 domain of α-Spectrin from Gallus gallus (residues 965-1025). Swissprot accession P07751. MW = 7.2 kDa.
Description : Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene.The spectrins are a family of widely-distributed cytoskeletal proteins which are involved in actin crosslinking. The protein enocoded by this gene is an spectrin alpha-chain which heterodimerizes with tissue-specific beta-chains.
Source : E.Coli.
Purity : > 95% by SDS-PAGE. The protein was observed as a single band migrating at molecular weight of <10 kDa.
Supplied As : 1.0mg/ml in 50mM Ammonium Acetate, pH 4.5. The concentration is calculated from the absorbance at 280nm (e280 = 15470 M-1 cm-1).
Characteristics : Under the above described conditions, the product has been concentrated up to 2mM without observing significant precipitation and/or protein aggregation.
Storage : -20ºC. The protein is stable at 4ºC for at least 2 weeks and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles.
PDB rendering based on 1aey. :

Gene Name : SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) [ Gallus gallus ]
Synonyms : SPTAN1; spectrin, alpha, non-erythrocytic 1(alpha-fodrin); SPECA; actin binding; calcium ion binding; calmodulin binding; alpha-spectrin; spectrin alpha chain; nonerythroid alpha-spectrin
Gene ID : 374234
mRNA Refseq : NM_001042538
Protein Refseq : NP_001036003
UniProt ID : P07751
Function : actin binding; calcium ion binding; calmodulin binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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