Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain SPTAN1-468C

Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain

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Recombinant Chicken Spectrin, Alpha, Non-erythrocytic 1 (Alpha-fodrin), SH3 Domain

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Cat. No. : SPTAN1-468C
Product Overview : Recombinant chickenα-Spectrin domain SH3 (Spectrin, non-erythroid alpha chain, Fodrin alpha chain) cloned from cDNA from chicken was expressed inE. coli. It consists of the soluble SH3 domain of α-Spectrin from Gallus gallus (residues 965-1025). Swissprot accession P07751. MW = 7.2 kDa.
Description : Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene.The spectrins are a family of widely-distributed cytoskeletal proteins which are involved in actin crosslinking. The protein enocoded by this gene is an spectrin alpha-chain which heterodimerizes with tissue-specific beta-chains.
Source : E.Coli.
Purity : > 95% by SDS-PAGE. The protein was observed as a single band migrating at molecular weight of <10 kDa.
Supplied As : 1.0mg/ml in 50mM Ammonium Acetate, pH 4.5. The concentration is calculated from the absorbance at 280nm (e280 = 15470 M-1 cm-1).
Characteristics : Under the above described conditions, the product has been concentrated up to 2mM without observing significant precipitation and/or protein aggregation.
Storage : -20ºC. The protein is stable at 4ºC for at least 2 weeks and at 25ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20ºC. Avoid repeated freeze/defrost cycles.
PDB rendering based on 1aey. :

Gene Name : SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) [ Gallus gallus ]
Synonyms : SPTAN1; spectrin, alpha, non-erythrocytic 1(alpha-fodrin); SPECA; actin binding; calcium ion binding; calmodulin binding; alpha-spectrin; spectrin alpha chain; nonerythroid alpha-spectrin
Gene ID : 374234
mRNA Refseq : NM_001042538
Protein Refseq : NP_001036003
UniProt ID : P07751
Function : actin binding; calcium ion binding; calmodulin binding

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