Recombinant Human DKK3 protein, His-tagged
Cat.No. : | DKK3-685H |
Product Overview : | Recombinant Human DKK3 (Pro23-Ile350) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Pro23 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 37.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Pro23-Ile350 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Publication : |
Use of tumor suppressor genes of naked mole rats for human cancer treatment (2023)
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Gene Name : | DKK3 |
Official Symbol : | DKK3 |
Synonyms : | DKK3; dickkopf 3 homolog (Xenopus laevis); dickkopf (Xenopus laevis) homolog 3; dickkopf-related protein 3; regulated in glioma; REIC; RIG; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG-like 7-1; dickkopf homolog 3 |
Gene ID : | 27122 |
mRNA Refseq : | NM_001018057 |
Protein Refseq : | NP_001018067 |
MIM : | 605416 |
UniProt ID : | Q9UBP4 |
Products Types
◆ Recombinant Protein | ||
DKK3-2667H | Recombinant Human DKK3 Protein, GST-tagged | +Inquiry |
DKK3-2219H | Recombinant Human DKK3 Protein, MYC/DDK-tagged | +Inquiry |
Dkk3-199M | Recombinant Mouse Dkk3 Protein, His-tagged | +Inquiry |
Dkk3-2572M | Recombinant Mouse Dkk3 Protein, Myc/DDK-tagged | +Inquiry |
DKK3-001H | Active Recombinant Human DKK3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DKK3-2672MCL | Recombinant Mouse DKK3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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