Expand Expand| Cat.No. : | IL6ST-787H |
| Product Overview : | Recombinant Human IL6ST aa. (Thr392~Leu566 (Accession # P40189)) fused with N-terminal His tag was produced in E. coli cells. |
| Description : | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | Freeze-dried powder |
| Molecular Mass : | Predicted Molecular Mass: 20.3kDa |
| Protein length : | Thr392~Leu566 (Accession # P40189) |
| Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
| Purity : | > 95% |
| Characteristic : | The isoelectric point is 5.9. |
| Applications : | SDS-PAGE; WB; ELISA; IP |
| Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
| Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4 |
| Gene Name : | IL6ST interleukin 6 signal transducer [ Homo sapiens (human) ] |
| Official Symbol : | IL6ST |
| Synonyms : | IL6ST; interleukin 6 signal transducer; CD130; GP130; CDW130; IL-6RB; interleukin-6 receptor subunit beta; CD130 antigen; IL-6 receptor subunit beta; IL-6R subunit beta; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; interleukin receptor beta chain; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha |
| Gene ID : | 3572 |
| mRNA Refseq : | NM_001190981.1 |
| Protein Refseq : | NP_001177910.1 |
| UniProt ID : | P40189 |
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