Cat.No. : |
IL6ST-787H |
Product Overview : |
Recombinant Human IL6ST aa. (Thr392~Leu566 (Accession # P40189)) fused with N-terminal His tag was produced in E. coli cells. |
Description : |
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
Source : |
E. coli |
Species : |
Human |
Tag : |
His |
Form : |
Freeze-dried powder |
Molecular Mass : |
Predicted Molecular Mass: 20.3kDa |
Protein length : |
Thr392~Leu566 (Accession # P40189) |
Endotoxin : |
<1.0EU per 1µg (determined by the LAL method) |
Purity : |
> 95% |
Characteristic : |
The isoelectric point is 5.9. |
Applications : |
SDS-PAGE; WB; ELISA; IP |
Stability : |
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : |
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : |
Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
Reconstitution : |
Reconstitute in sterile PBS, pH7.2-pH7.4 |