Expand
Expand
| Cat.No.: | IL6ST-787H |
| Product Overview: | Recombinant Human IL6ST aa. (Thr392~Leu566 (Accession # P40189)) fused with N-terminal His tag was produced in E. coli cells. |
| Description: | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
| Source: | E. coli |
| Species: | Human |
| Tag : | His |
| Form: | Freeze-dried powder |
| Molecular Mass: | Predicted Molecular Mass: 20.3kDa |
| Protein length: | Thr392~Leu566 (Accession # P40189) |
| Endotoxin: | <1.0EU per 1µg (determined by the LAL method) |
| Purity: | > 95% |
| Characteristic: | The isoelectric point is 5.9. |
| Applications: | SDS-PAGE; WB; ELISA; IP |
| Stability: | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage: | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Storage buffer: | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
| Reconstitution: | Reconstitute in sterile PBS, pH7.2-pH7.4 |
| Gene Name: | IL6ST interleukin 6 signal transducer [ Homo sapiens (human) ] |
| Official Symbol: | IL6ST |
| Synonyms: | IL6ST; interleukin 6 signal transducer; CD130; GP130; CDW130; IL-6RB; interleukin-6 receptor subunit beta; CD130 antigen; IL-6 receptor subunit beta; IL-6R subunit beta; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; interleukin receptor beta chain; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha |
| Gene ID: | 3572 |
| mRNA Refseq: | NM_001190981.1 |
| Protein Refseq: | NP_001177910.1 |
| UniProt ID: | P40189 |
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Download Datasheet
See All IL6ST Products
Download Datasheet