Recombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera


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Recombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera

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Cat. No. : FGFR2-595H
Product Overview : Recombinant human soluble FGFR-2á (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-2á (IIIc) is a disulfide-linked heterodimeric protein. The reduced form of human FGF -R2á (IIIc)/Fc is a monomer with a calculated molecular mass of approximately 66 kDa. As a result of glycosylation, the recombinant protein has a mass of 95-100 kDa. It is produced inE.coli.
Description : Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the á isoform, or only IgII and IgIII, referred to as the ß isoform. Only the á isoform has been identified for FGFR-3 and FGFR-4.
Source : E.coli.
Subunit : Glycosylated dimer.
Formulation : Lyophilized.
Endotoxin Level : < 0.1 ng per ug of sFGF-R2á.
Purity : > 90%, by SDS-PAGE and visualised by silver stain.
Reconstitution : The lyophilised sFGFR-2á (IIIc)/Fc is soluble in water and most aqueous buffers. The lyophilised sFGF-R2á (IIIc)/Fc should be reconstituted in PBS or medium to a concentration not l lower than 50µg/ml.
Biological Activity : Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.
Stability : Lyophilised samples are stable for greater than six months at –20°C to –70℃. Reconstituted sFGFR-2á (IIIc)/Fc should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles!
PDB rendering based on 1djs. :

Gene Name : FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
Synonyms : FGFR2; fibroblast growth factor receptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FLJ98662; BEK fibroblast growth factor receptor; FGF receptor; OTTHUMP00000020624; OTTHUMP00000020626; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; EC
Gene ID : 2263
mRNA Refseq : NM_000141
Protein Refseq : NP_000132
MIM : 176943
UniProt ID : P21802
Chromosome Location : 10q26
Pathway : Endocytosis; MAPK signaling pathway; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Signaling by FGFR
Function : ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; receptor activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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