Embryonic Ectoderm Development CBCRY07

Embryonic Ectoderm Development

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Embryonic Ectoderm Development

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Cat. No. : CBCRY07
Background : The crystal structure of EED in complex with a 30 residue peptide from EZH2 reveals that the peptide binds to the bottom of the WD-repeat domain of EED. The structural determinants of EZH2-EED interaction are present not only in EZH2 and EZH1 but also in its Drosophila homolog E(Z), suggesting that the recognition of ESC by E(Z) in Drosophila employs similar structural motifs. Structure-based mutagenesis identified critical residues from both EED and EZH2 for their interaction.
Protein Classification : gene regulation
Structure Weight : 45399.05 Da
Polymer : 1
Molecule : Embryonic ectoderm development
Chain Length : 361 amino acids
PDB ID : 2QXV
MMDB ID : 59571
Source : E.coli
Method : X-Ray Diffraction
Resolution : 1.82Å
Reference : Han, Z., Xing, X., Hu, M., Zhang, Y., Liu, P., Chai, J. (2007) Structural basis of EZH2 recognition by EED Structure 15: 1306-1315
Gene Name : Eed
Synonyms : embryonic ectoderm development; ENSMUSG00000039373; l(7)5Rn; l7Rn5; lusk; OTTMUSP00000023294; lethal; Chr 7; Rinchik 5
Chromosome Location : 7
Function : chromatin binding; histone methyltransferase binding; protein binding
Gene ID : 14056

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