Recombinant Mouse Il21 protein
Cat.No. : | Il21-169M |
Product Overview : | Recombinant Mouse Il21 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | E.coli |
Species : | Mouse |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 2 × PBS, pH 7.4. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of > 4.0 × 10⁴ IU/mg. |
Molecular Mass : | Approximately 15.0 kDa, a single non-glycosylated polypeptide chain containing 129 amino acids. |
Protein length : | 129 |
AA Sequence : | HKSSPQGPDRLLIRLRHLIDIVEQL KIYENDLDPELLSAPQDVKGHCEHA AFACFQKAKLKPSNPGNNKTFIIDL VAQLRRRLPARRGGKKQKHIAKCPS CDSYEKRTPKEFLERLKWLLQKMIH QHLS |
Endotoxin : | Less than 0.1 EU/μg of rMuIL-21 as determined by LAL method. |
Purity : | >98% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | Il21 |
Official Symbol : | Il21 |
Synonyms : | IL21; interleukin 21; interleukin-21; IL-21; |
Gene ID : | 60505 |
mRNA Refseq : | NM_021782 |
Protein Refseq : | NP_068554 |
UniProt ID : | Q9ES17 |
Products Types
◆ Recombinant Protein | ||
Il21-361I | Active Recombinant Mouse Il21 Protein (123 aa) | +Inquiry |
IL21-735H | Active Recombinant Human IL21 Protein | +Inquiry |
IL21-16H | Active Recombinant Human IL21 Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
IL21-263H | Active Recombinant Human IL21 Protein (Gln32-Ser162), C-His tagged, Animal-free, Carrier-free | +Inquiry |
Il21-3511M | Active Recombinant Mouse Il21 Protein | +Inquiry |
◆ Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.
Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.
IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.
Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.
IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.
Customer Reviews (3)
Write a reviewWith the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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