Recombinant Mouse Interleukin 31

• Cat.No.: Il31-171M
• Product Overview: Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues. It was expressed inE.Coli.

Specification

• Cat. No.: Il31 -171M
• Description: IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
• Source: E.Coli.
• Purity: > 98% (SDS-PAGE; HPLC).
• Endotoxin Level: < 0.1 ng/μg of IL-31.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Testing in progress.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-31 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: Il31 interleukin 31 [ Mus musculus ]
• Synonyms: interleukin 31; 1700013B14Rik; Il31
• Gene ID: 76399
• mRNA Refseq: NM_029594
• Protein Refseq: NP_083870
• UniProt ID: Q6EAL8
• Chromosome Location: 5 F
• Function: cytokine activity

Reviews

04/22/2022

IL31 product has strict quality control and complies with relevant industry standards.

09/26/2021

It performs well in biological activity tests.

09/13/2020

This protein has high yield and good economic benefits.

Q&As

What are the advantages of IL31 compared with other therapeutic methods?

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31?

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory?

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31?

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31?

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment?

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.