Recombinant Human Delta-like 4 (Drosophila)

• Cat.No.: DLL4-934H
• Product Overview: Recombinant human sDLL4 produced in293 cellsis a 54.0 kDa glycoprotein containing 498 amino-acid residues.

Specification

• Cat. No.: DLL4-934H
• Description: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors.
• Source: 293 cells.
• Purity: > 95%, by SDS-PAGE and HPLC analysis.
• Endotoxin level: < 0.1 ng per μg of sDLL-4.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: The sDLL-4, when immobilized at concentrations >1.5μg/mL will inhibit myogenesis in C2C12 cells.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: DLL4 delta-like 4 (Drosophila) [ Homo sapiens ]
• Synonyms: DLL4; delta-like 4 (Drosophila); hdelta2; MGC126344; delta-like 4 protein; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; notch ligand delta-2; Drosophila Delta homolog; delta-like 4 homolog (Drosophila)
• Gene ID: 54567
• mRNA Refseq: NM_019074
• Protein Refseq: NP_061947
• MIM: 605185
• UniProt ID: Q9NR61
• Chromosome Location: 15q14
• Pathway: Notch signaling pathway
• Function: Notch binding; calcium ion binding; protein binding

Reviews

07/29/2022

They ensure a consistent and reliable supply of DLL4 protein, minimizing any potential disruptions in my experimental workflow.

05/01/2021

the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

12/09/2017

This collaborative approach empowers me to integrate cutting-edge knowledge, explore innovative techniques, and expand the impact of my research.

Q&As

What role does DLL4 play in vascular diseases, such as atherosclerosis?

DLL4 is implicated in the regulation of vascular inflammation and plaque formation, making it a potential target for atherosclerosis treatments.

How does DLL4 contribute to Alzheimer's disease pathogenesis?

DLL4 has been linked to Alzheimer's disease as it can influence amyloid-beta accumulation and the activation of microglia in the brain.

Can DLL4 be used as a biomarker for any diseases?

DLL4 levels can serve as a potential biomarker in some diseases, such as certain cancers, where it may indicate disease progression.

What are the challenges in developing DLL4-targeted therapies?

Challenges include potential side effects, the need for personalized treatment approaches, and the complexity of the Notch signaling pathway.

How does DLL4 affect tissue regeneration?

DLL4 can modulate tissue regeneration by influencing stem cell behavior and promoting tissue repair processes.