"DLL4" Related Products

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Recombinant Human Delta-like 4 (Drosophila)

Cat. No.: DLL4-934H
Product Overview: Recombinant human sDLL4 produced in293 cellsis a 54.0 kDa glycoprotein containing 498 amino-acid residues.
Description: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors.
Source: 293 cells.
Purity: > 95%, by SDS-PAGE and HPLC analysis.
Endotoxin level: < 0.1 ng per μg of sDLL-4.
Stabilizer: None.
Formulation: Lyophilized.
Biologically Activity: The sDLL-4, when immobilized at concentrations >1.5μg/mL will inhibit myogenesis in C2C12 cells.
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Gene Name: DLL4 delta-like 4 (Drosophila) [ Homo sapiens ]
Synonyms: DLL4; delta-like 4 (Drosophila); hdelta2; MGC126344; delta-like 4 protein; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; notch ligand delta-2; Drosophila Delta homolog; delta-like 4 homolog (Drosophila)
Gene ID: 54567
mRNA Refseq: NM_019074
Protein Refseq: NP_061947
MIM: 605185
UniProt ID: Q9NR61
Chromosome Location: 15q14
Pathway: Notch signaling pathway
Function: Notch binding; calcium ion binding; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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