Cat. No.: | ZGLP1-941H |
Product Overview: | Recombinant human GLP-1 produced inE.coliis a 3.3 kDa consisting of 31 amino acid residues. |
Description: | GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is stimulation of pancreatic β-cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include suppression of plasma glucagons levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. |
Source: | E.coli. |
Purity: | 98 % (SDS-PAGE, HPLC). |
Endotoxin level: | < 0.1 ng per ug of GLP-1. |
Stabilizer: | None. |
Formulation: | Lyophilized. |
Biologically Activity: | Data not available! |
Stability: | The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GLP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles. |
Gene Name: | ZGLP1 zinc finger, GATA-like protein 1 [ Homo sapiens ] |
Synonyms: | ZGLP1; zinc finger, GATA-like protein 1; GLP1; GLP-1; FLJ39511; FLJ39703; GATA like protein 1 |
Gene ID: | 100125288 |
mRNA Refseq: | NM_001103167 |
Protein Refseq: | NP_001096637 |
MIM: | 611639 |
UniProt ID: | P0C6A0 |
Chromosome Location: | 19p13.2 |
Function: | metal ion binding; sequence-specific DNA binding; transcription factor activity; transcription repressor activity; zinc ion binding |
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