Recombinant Human Intercellular Adhesion Molecule 1

• Cat.No.: ICAM1-946H
• Product Overview: Recombinant human ICAM-1 produced inCHO cellsis a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.

Specification

• Cat. No.: ICAM1-946H
• Description: ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain.
• Source: CHO cells.
• Purity: >98 % (SDS-PAGE, HPLC).
• Endotoxin Level: < 0.1 ng per ug of ICAM-1.
• Stabilizer: None.
• Formulation: Lyophilized.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted ICAM-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃.

Gene Information

• Gene Name: ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ]
• Synonyms: ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; human rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54 antigen; cell surface glycoprotein P3.58; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
• Gene ID: 3383
• mRNA Refseq: NM_000201
• Protein Refseq: NP_000192
• MIM: 147840
• UniProt ID: P05362
• Chromosome Location: 19p13.3-p13.2
• Pathway: Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Integrin cell surface interactions; Signaling in Immune system
• Function: integrin binding ; protein binding ; transmembrane receptor activity