"ICAM1" Related Products


Recombinant Human Intercellular Adhesion Molecule 1

Cat. No. : ICAM1-946H
Product Overview : Recombinant human ICAM-1 produced inCHO cellsis a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Description : ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain.
Source : CHO cells.
Purity : >98 % (SDS-PAGE, HPLC).
Endotoxin Level : < 0.1 ng per ug of ICAM-1.
Stabilizer : None.
Formulation : Lyophilized.
Stability : The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted ICAM-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃.
Gene Name : ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ]
Synonyms : ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; human rhinovirus receptor; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54 antigen; cell surface glycoprotein P3.58; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
Gene ID : 3383
mRNA Refseq : NM_000201
Protein Refseq : NP_000192
MIM : 147840
UniProt ID : P05362
Chromosome Location : 19p13.3-p13.2
Pathway : Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity; Integrin cell surface interactions; Signaling in Immune system
Function : integrin binding ; protein binding ; transmembrane receptor activity

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