Recombinant Human TNFRSF4

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Recombinant Human TNFRSF4

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Cat. No. : TNFRSF4-967H
Product Overview : Recombinant human OX40L produced inInsect cellsis a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 – 25.0 kDa on SDS-PAGE.
Description : OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance.
Source : Insect cells.
Purity : > 97%, by SDS-PAGE and HPLC analysis.
Endotoxin Level : < 0.1 ng perugof sOX40 Ligand.
Stabilizer : None.
Formulation : Lyophilized.
Biological Activity : Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors.
Stability : The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted sOX40 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at-20℃. Avoid repeated freeze-thaw cycles.
PDB rendering based on 2hev. :

Gene Name : TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ]
Synonyms : tumor necrosis factor receptor superfamily, member 4; OX40; ACT35; CD134; TXGP1L; TNFRSF4; tax-transcriptionally activated glycoprotein 1 receptor; lymphoid activation antigene ACT35; OX40 cell surface antigen; OX40 homologue; CD134 antigen; ATC35 antigen; OX40 antigen; OTTHUMP00000001522; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor
Gene ID : 7293
mRNA Refseq : NM_003327
Protein Refseq : NP_003318
MIM : 600315
UniProt ID : P43489
Chromosome Location : 1p36
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity; tumor necrosis factor receptor activity

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