"TNFRSF13B" Related Products

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Recombinant Human TNFRSF13B

Cat. No.: TNFRSF13B-970H
Product Overview: Recombinant human TACI produced inE.coliis a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.
Description: TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor.
Source: E.coli.
Purity: > 98% by SDS-PAGE and HPLC analysis.
Endotoxin Level: < 0.1 ng per ug of TACI.
Stabilizer: None.
Formulation: Lyophilized.
Biological Activity: Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 μg/ml.
Reconstitution: The human TACI should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20℃.
Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20℃. Reconstituted human TACI should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles.
Gene Name: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
Synonyms: TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; CVID; TACI; CD267; FLJ39942; MGC39952; MGC133214; TNFRSF14B; Tumor necrosis factor receptor superfamily member 13B;Transmembrane activator and CAML interactor; OTTHUMP00000065442; CD267 antigen; tumor necrosis factor receptor 13B
Gene ID: 23495
mRNA Refseq: NM_012452
Protein Refseq: NP_036584
MIM: 604907
UniProt ID: O14836
Chromosome Location: 17p11.2
Pathway: Cytokine-cytokine receptor interaction; Primary immunodeficiency
Function: protein binding; receptor activity

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