"GDF6" Related Products

Recombinant Human Growth Differentiation Factor 6

Cat. No. : GDF6-19H
Product Overview : Recombinant HumanGDF6 produced inE.coliwas a 27.0kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.This 27.5kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa.
Description : BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains.
Source : E.coli.
Purity : >95% by SDS-PAGE.
Endotoxin Level : <0.1ng/μg of BMP-13.
Stabilizer : None.
Formulation : Lyophilized.
Biologically Activity : The ED50was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0μg/ml.
Reconstitution : The human BMP-13 should be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Stability : The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human BMP-13 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name : GDF6 growth differentiation factor 6 [ Homo sapiens ]
Synonyms : GDF6; growth differentiation factor 6; KFSL; KFS; GDF16; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MGC158100; MGC158101; Growth/differentiation factor 6; Growth/differentiation factor 16
Gene ID : 392255
mRNA Refseq : NM_001001557.2
Protein Refseq : NP_001001557.1
MIM : 601147
UniProt ID : Q6KF10
Chromosome Location : 8q22.1
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : cytokine activity; growth factor activity

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