Recombinant Human Bone Morphogenetic Protein 4

• Cat.No.: BMP4-20H
• Product Overview: Recombinant human BMP-4 expressed inHeLa cellswas a 31-36kDa homodimeric glycoprotein.

Specification

• Cat. No.: BMP4-20H
• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder fibrodysplasia ossificans progressiva.
• Source: HeLa cells.
• Purity: >97% by SDS-PAGE and HPLC analysis.
• Endotoxin Level: <0.1ng/μg of BMP-4.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20oC. Reconstituted BMP-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20oC. Avoid repeated freeze-thaw cycles!

Gene Information

• Gene Name: BMP4 bone morphogenetic protein 4 [ Homo sapiens ]
• Synonyms: ZYME; BMP2B; BMP2B1; DVR4; MCOPS6; BMP-2B; BMP-4; Bone morphogenetic protein 4 precursor; bone morphogenetic protein 2B; bone morphogenetic protein 4; BMP4
• Gene ID: 652
• mRNA Refseq: NM_001202
• Protein Refseq: NP_001193
• MIM: 112262
• UniProt ID: P12644
• Chromosome Location: 14q22-q23
• Function: cytokine activity; growth factor activity; heparin binding; protein binding; signal transducer activity