||Recombinant human BMP-4 expressed inHeLa cellswas a 31-36kDa homodimeric glycoprotein.
||Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder fibrodysplasia ossificans progressiva.
||>97% by SDS-PAGE and HPLC analysis.
||<0.1ng/μg of BMP-4.
||Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
||The lyophilized protein is stable for at least 2 years from date of receipt at -20oC. Reconstituted BMP-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20oC. Avoid repeated freeze-thaw cycles!